Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain
dc.contributor.author | Levin, Raquel [UNIFESP] | |
dc.contributor.author | Peres, Fernanda Fiel [UNIFESP] | |
dc.contributor.author | Almeida, Valeria [UNIFESP] | |
dc.contributor.author | Calzavara, Mariana Bendlin [UNIFESP] | |
dc.contributor.author | Zuardi, Antonio W. | |
dc.contributor.author | Hallak, Jaime E. C. | |
dc.contributor.author | Crippa, Jose Alexandre S. | |
dc.contributor.author | Abilio, Vanessa Costhek [UNIFESP] | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Natl Council Sci & Technol Dev | |
dc.date.accessioned | 2016-01-24T14:35:18Z | |
dc.date.available | 2016-01-24T14:35:18Z | |
dc.date.issued | 2014-02-06 | |
dc.description.abstract | Clinical and neurobiological findings suggest that the cannabinoids and the endocannabinoid system may be implicated in the pathophysiology and treatment of schizophrenia. We described that the spontaneously hypertensive rats (SHR) strain presents a schizophrenia behavioral phenotype that is specifically attenuated by antipsychotic drugs, and potentiated by proschizophrenia manipulations. Based on these findings, we have suggested this strain as an animal model of schizophrenia. the aim of this study was to evaluate the effects of cannabinoid drugs on the deficit of prepulse inhibition (PPI) of startle, the main paradigm used to study sensorimotor gating impairment related to schizophrenia, presented by the SHR strain. the following drugs were used: (1) WIN55212,2 (cannabinoid agonist), (2) rimonabant (CB1 antagonist), (3) AM404 (anandamide uptake inhibitor), and (4) cannabidiol (CBD; indirect CB1/CB2 receptor antagonist, among other effects). VVistar rats (VVRs) and SHRs were treated with vehicle (VEH) or different doses of WIN55212 (0.3, 1, or 3 mg/kg), rimonabant (0.75, 1.5, or 3 mg/kg), AM404 (1, 5, or 10 mg/kg), or CBD (15, 30, or 60 mg/kg). VEH-treated SHRs showed a decreased PPI when compared to VVRs. This PPI deficit was reversed by 1 mg/kg WIN and 30 mg/kg CBD. Conversely, 0.75 mg/kg rimonabant decreased PPI in SHR strain, whereas AM404 did not modify it. Our results reinforce the role of the endocannabinoid system in the sensorimotor gating impairment related to schizophrenia, and point to cannabinoid drugs as potential therapeutic strategies. | en |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Pharmacol, BR-04039032 São Paulo, Brazil | |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin, BR-04039032 São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Dept Neurosci & Behav, BR-14049 Ribeirao Preto, Brazil | |
dc.description.affiliation | Natl Council Sci & Technol Dev, Natl Inst Sci & Technol Translat Med, Ribeirao Preto, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Pharmacol, BR-04039032 São Paulo, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin, BR-04039032 São Paulo, Brazil | |
dc.description.source | Web of Science | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipID | FAPESP: FAPESP - 2010/07994-3 | |
dc.format.extent | 10 | |
dc.identifier | http://dx.doi.org/10.3389/fphar.2014.00010 | |
dc.identifier.citation | Frontiers in Pharmacology. Lausanne: Frontiers Research Foundation, v. 5, 10 p., 2014. | |
dc.identifier.doi | 10.3389/fphar.2014.00010 | |
dc.identifier.file | WOS000347041400001.pdf | |
dc.identifier.issn | 1663-9812 | |
dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/37432 | |
dc.identifier.wos | WOS:000347041400001 | |
dc.language.iso | eng | |
dc.publisher | Frontiers Research Foundation | |
dc.relation.ispartof | Frontiers in Pharmacology | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | schizophrenia | en |
dc.subject | SHR | en |
dc.subject | PPI | en |
dc.subject | cannabinoid drugs | en |
dc.subject | animal model | en |
dc.title | Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain | en |
dc.type | info:eu-repo/semantics/article |
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