Ghrelin and GHRP-6-induced ACTH and cortisol release in thyrotoxicosis

Página do item simplificado
dc.contributor.authorNascif, Sergio Oliva [UNIFESP]
dc.contributor.authorMolica, Patricia [UNIFESP]
dc.contributor.authorCorrea-Silva, Silvia Regina [UNIFESP]
dc.contributor.authorSilva, Marcos Roberto [UNIFESP]
dc.contributor.authorLengyel, Ana-Maria Judith [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:57Z
dc.date.available2016-01-24T13:58:57Z
dc.date.issued2009-12-01
dc.description.abstractThyrotoxicosis might alter the hypothalamic-pituitary-adrenal (HPA) axis. We evaluated the effects of ghrelin and GHRP-6 on the HPA axis in 20 hyperthyroid patients and in 9 controls. Mean basal cortisol (mu g/dl) and ACTH (pg/ml) levels were higher in hyperthyroidism (cortisol: 10.7 +/- A 0.7; ACTH: 21.5 +/- A 2.9) compared to controls (cortisol: 8.1 +/- A 0.7; ACTH: 13.5 +/- A 1.8). in thyrotoxicosis a dagger AUC cortisol values (mu g/dl.90 min) after ghrelin (484 +/- A 80) and GHRP-6 (115 +/- A 63) were similar to controls (ghrelin: 524 +/- A 107; GHRP-6: 192 +/- A 73). A significant increase in a dagger AUC ACTH (pg/ml.90 min) after ghrelin was observed in thyrotoxicosis (4,189 +/- A 1,202) compared to controls (1,499 +/- A 338). a dagger AUC ACTH values after GHRP-6 were also higher, although not significantly (patients: 927 +/- A 330; controls: 539 +/- A 237). in summary, our results suggest that ghrelin-mediated pathways of ACTH release might be activated by thyroid hormone excess, but adrenocortical reserve is maintained.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Endocrinol, EPM, BR-04039002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Endocrinol, EPM, BR-04039002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent315-321
dc.identifierhttp://dx.doi.org/10.1007/s11102-009-0181-3
dc.identifier.citationPituitary. New York: Springer, v. 12, n. 4, p. 315-321, 2009.
dc.identifier.doi10.1007/s11102-009-0181-3
dc.identifier.issn1386-341X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31982
dc.identifier.wosWOS:000270977600006
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofPituitary
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectGhrelinen
dc.subjectACTHen
dc.subjectCortisolen
dc.subjectThyrotoxicosisen
dc.titleGhrelin and GHRP-6-induced ACTH and cortisol release in thyrotoxicosisen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos