Aberrant DNA methylation of ESR1 and p14ARF genes could be useful as prognostic indicators in osteosarcoma

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dc.contributor.authorSonaglio, Viviane
dc.contributor.authorCarvalho, Ana Carolina de [UNIFESP]
dc.contributor.authorToledo, Silvia Regina Caminada de [UNIFESP]
dc.contributor.authorSouza, Carolina Salinas de [UNIFESP]
dc.contributor.authorCarvalho, Andre L.
dc.contributor.authorPetrilli, Antonio Sergio [UNIFESP]
dc.contributor.authorCamargo, Beatriz de
dc.contributor.authorVettore, Andre L. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionBarretos Canc Hosp
dc.contributor.institutionInst Nacl Canc
dc.date.accessioned2016-01-24T14:30:56Z
dc.date.available2016-01-24T14:30:56Z
dc.date.issued2013-01-01
dc.description.abstractOsteosarcoma (OS) is the eighth most common form of childhood and adolescence cancer. Approximately 10%-20% of patients present metastatic disease at diagnosis and the 5-year overall survival remains around 70% for nonmetastatic patients and around 30% for metastatic patients. Metastatic disease at diagnosis and the necrosis grade induced by preoperative treatment are the only well-established prognostic factors for osteosarcoma. the DNA aberrant methylation is a frequent epigenetic alteration in humans and has been described as a molecular marker in different tumor types. This study evaluated the DNA aberrant methylation status of 18 genes in 34 OS samples without previous chemotherapy treatment and in four normal bone specimens and compared the methylation profile with clinicopathological characteristics of the patients. We were able to define a three-gene panel (AIM1, p14ARF, and ESR1) in which methylation was correlated with OS cases. the hypermethylation of p14ARF showed a significant association with the absence of metastases at diagnoses, while ESR1 hypermethylation was marginally associated with worse overall survival. This study demonstrated that aberrant promoter methylation is a common event in OS and provides evidence that p14ARF and ESR1 hypermethylation could be useful as a prognostic indicator for this disease.en
dc.description.affiliationAC Camargo Hosp, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biol Sci, Diadema, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, GRAACC, Dept Pediat, Pediat Oncol Inst, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, São Paulo, Brazil
dc.description.affiliationBarretos Canc Hosp, Dept Head & Neck Surg, PIO Fdn 12, São Paulo, Brazil
dc.description.affiliationInst Nacl Canc, Res Program Pediat Oncol Program, CPNq, Rio de Janeiro, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biol Sci, Diadema, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, GRAACC, Dept Pediat, Pediat Oncol Inst, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundacao Antonio Prudente (FAP)
dc.description.sponsorshipIDCNPq: 472193/2004-0
dc.format.extent713-723
dc.identifierhttp://dx.doi.org/10.2147/OTT.S44918
dc.identifier.citationOncotargets and Therapy. Albany: Dove Medical Press Ltd, v. 6, p. 713-723, 2013.
dc.identifier.doi10.2147/OTT.S44918
dc.identifier.issn1178-6930
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35733
dc.identifier.wosWOS:000320437500001
dc.language.isoeng
dc.publisherDove Medical Press Ltd
dc.relation.ispartofOncotargets and Therapy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDNA methylationen
dc.subjectESR1en
dc.subjecthypermethylationen
dc.subjectosteosarcomaen
dc.subjectp14ARFen
dc.titleAberrant DNA methylation of ESR1 and p14ARF genes could be useful as prognostic indicators in osteosarcomaen
dc.typeinfo:eu-repo/semantics/article
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