Lesions of the commissural subnucleus of the nucleus of the solitary tract increase isoproterenol-induced water intake

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dc.contributor.authorBlanch, Graziela Torres
dc.contributor.authorFreiria-Oliveira, Andre Henrique
dc.contributor.authorColombari, Eduardo [UNIFESP]
dc.contributor.authorMenani, Jose Vanderlei
dc.contributor.authorColombari, Debora Simões de Almeida [UNIFESP]
dc.contributor.institutionUNESP
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:48:54Z
dc.date.available2016-01-24T13:48:54Z
dc.date.issued2007-08-01
dc.description.abstractThe nucleus of the solitary tract (NTS) is the primary site of the cardiovascular afferent information about arterial blood pressure and volume. the NTS projects to areas in the central nervous system involved in cardiovascular regulation and hydroelectrolyte balance, such as the anteroventral third ventricle region and the lateral parabrachial nucleus. the aim of the present study was to investigate the effects of electrolytic lesion of the commissural NTS on water and 0.3 M NaCl intake and the cardiovascular responses to subcutaneous injection of isoproterenol. Male Holtzman rats weighing 280 to 320 g were submitted to sham lesion or electrolytic lesion of the commissural NTS (N = 6-15/group). the sham-lesioned rats had the electrode placed along the same coordinates, except that no current was passed. Water intake induced by subcutaneous isoproterenol (30 mu g/kg body weight) significantly increased in chronic (15 days) commissural NTS-lesioned rats (to 2.4 +/- 0.2 vs sham: 1.9 +/- 0.2 mL 100 g body weight(-1) 60 min(-1)). Isoproterenol did not induce any sodium intake in sham or in commissural NTS-lesioned rats. the isoproterenol-induced hypotension (sham: -27 +/- 4 vs commissural NTS-lesioned rats: -22 +/- 4 mmHg/20 min) and tachycardia (sham: 168 +/- 10 vs commissural NTS: 144 +/- 24 bpm/20 min) were not different between groups. the present results suggest that the commissural NTS is part of an inhibitory neural pathway involved in the control of water intake induced by subcutaneous isoproterenol, and that the overdrinking observed in lesioned rats is not the result of a cardiovascular imbalance in these animals.en
dc.description.affiliationUNESP, Fac Odontol, Dept Fisiol & Patol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1121-1127
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2006005000139
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 40, n. 8, p. 1121-1127, 2007.
dc.identifier.doi10.1590/S0100-879X2006005000139
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2006005000139
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29897
dc.identifier.wosWOS:000248413400013
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectnucleus of the solitary tracten
dc.subjectcommissural nucleus of the rat solitary tracten
dc.subjectwater intakeen
dc.subjectarterial pressureen
dc.subjectisoproterenolen
dc.subjecthindbrainen
dc.titleLesions of the commissural subnucleus of the nucleus of the solitary tract increase isoproterenol-induced water intakeen
dc.typeinfo:eu-repo/semantics/article
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