Environmental novelty and illumination modify ethanol-induced open-field behavioral effects in mice

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dc.contributor.authorFukushiro, Daniela F. [UNIFESP]
dc.contributor.authorBenetti, Liliane F. [UNIFESP]
dc.contributor.authorJosino, Fabiana S. [UNIFESP]
dc.contributor.authorOliveira, Gabriela P. [UNIFESP]
dc.contributor.authorFernandes, Maiara deM. [UNIFESP]
dc.contributor.authorSaito, Luis P. [UNIFESP]
dc.contributor.authorUehara, Regina A. [UNIFESP]
dc.contributor.authorWuo-Silva, Raphael [UNIFESP]
dc.contributor.authorOliveira, Camila S. [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:25Z
dc.date.available2016-01-24T13:59:25Z
dc.date.issued2010-03-01
dc.description.abstractBoth spontaneous and drug-induced animal behaviors can be modified by exposure to novel stimuli or different levels of environmental illumination. However, research into how these factors specifically impact ethanol (ETH)-induced behavioral effects is currently lacking. We aimed to investigate the effects of these two factors, considered separately or in conjunction, on ETH-induced acute hyperloconnotor effect and its sensitization in adult male Swiss mice. Mice were placed in a novel or familiar open-field under normal light (200 lx) or low light (9 lx) immediately after receiving an ip injection of either 1.8 g/kg ETH or saline (SAL). After 7 days, all animals received an ip challenge injection of 1.8 g/kg ETH, and were placed in the open-field under the same light conditions described above. Novelty increased central locomotion and decreased grooming, while low light increased grooming. Acute ETH administration increased both total and peripheral locomotion and these effects were potentiated by low light. Both low light and novelty were able to facilitate ETH-induced locomotor sensitization, which was detected by the central locomotion parameter. However, there was no synergism between the effects of these two modulating factors on ETH-induced behavioral sensitization. We conclude that both the acute behavioral effects of ETH and behavioral sensitization induced by previous administration of this drug can be critically modified by environmental factors. in addition, our study stresses the importance of using different behavioral parameters to evaluate the interaction between environmental factors and ETH effects. (C) 2009 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundo de Apoio ao Docente e Aluno (FADA)
dc.description.sponsorshipAssociacao Fundo de Pesquisa em Psicobiologia (AFIP)
dc.format.extent13-22
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2009.12.001
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 95, n. 1, p. 13-22, 2010.
dc.identifier.doi10.1016/j.pbb.2009.12.001
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32344
dc.identifier.wosWOS:000275617800003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectBehavioral sensitizationen
dc.subjectEthanolen
dc.subjectLight intensityen
dc.subjectLocomotionen
dc.subjectMiceen
dc.subjectNovel environmenten
dc.titleEnvironmental novelty and illumination modify ethanol-induced open-field behavioral effects in miceen
dc.typeinfo:eu-repo/semantics/article
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