Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes

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dc.contributor.authorRopert, C.
dc.contributor.authorFerreira, LRP
dc.contributor.authorCampos, MAS
dc.contributor.authorProcopio, D. O.
dc.contributor.authorTravassos, L. R.
dc.contributor.authorFerguson, MAJ
dc.contributor.authorReis, LFL
dc.contributor.authorTeixeira, M. M.
dc.contributor.authorAlmeida, I. C.
dc.contributor.authorGazzinelli, R. T.
dc.contributor.institutionFiocruz MS
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionLudwig Inst Canc Res
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Dundee
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T12:33:26Z
dc.date.available2016-01-24T12:33:26Z
dc.date.issued2002-07-01
dc.description.abstractActivation of cells from the innate immune system has an important role in host resistance to early infection with the intracellular protozoan parasite, Trypanosoma cruzi. Here we review the studies that have identified and structurally characterized the glycosylphosphatidylinositol (GPI) anchors, as parasite molecules responsible for the activation of cells from the macrophage lineage. We also cover the studies that have identified the receptor, signaling pathways as well as the array of genes expressed in macrophages that are activated by these glycoconjugates. We discuss the possible-implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.en
dc.description.affiliationFiocruz MS, CPqRR, Immunopathol Lab, BR-30190002 Belo Horizonte, MG, Brazil
dc.description.affiliationUFMG, ICB, Dept Biochem & Immunol, BR-31270901 Belo Horizonte, MG, Brazil
dc.description.affiliationLudwig Inst Canc Res, BR-01509010 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Expt Oncol Unit, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Dundee, Dept Biochem, Dundee DD1 5EH, Scotland
dc.description.affiliationUniv São Paulo, ICB, Dept Parasitol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Expt Oncol Unit, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1015-1025
dc.identifierhttp://dx.doi.org/10.1016/S1286-4579(02)01609-X
dc.identifier.citationMicrobes and Infection. Paris Cedex 15: Editions Scientifiques Medicales Elsevier, v. 4, n. 9, p. 1015-1025, 2002.
dc.identifier.doi10.1016/S1286-4579(02)01609-X
dc.identifier.issn1286-4579
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26912
dc.identifier.wosWOS:000178156700017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMicrobes and Infection
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectTrypanosoma cruzien
dc.subjectGPI anchorsen
dc.subjectTLR-2en
dc.subjectmacrophagesen
dc.subjectchemokinesen
dc.titleMacrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotesen
dc.typeinfo:eu-repo/semantics/article
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