The association between coronary artery calcification progression and loss of bone density in non-dialyzed CKD patients

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dc.contributor.authorWatanabe, Renato [UNIFESP]
dc.contributor.authorLemos, Marcelo Montebello [UNIFESP]
dc.contributor.authorCarvalho, Aluizio Barbosa de [UNIFESP]
dc.contributor.authorRochitte, Carlos Eduardo
dc.contributor.authorSantos, Raul D.
dc.contributor.authorDraibe, Sergio A. [UNIFESP]
dc.contributor.authorCanziani, Maria Eugenia [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:28:08Z
dc.date.available2016-01-24T14:28:08Z
dc.date.issued2012-12-01
dc.description.abstractBackground: Coronary artery calcification (CAC) and low bone density are coexisting deleterious conditions commonly shared by chronic kidney disease (CKD) patients. in the present study, we aimed to investigate whether the progression of CAC was associated with overtime reduction in bone density in non-dialyzed CKD patients. Methods: This is a prospective study of 24 months including 72 non-dialyzed CKD patients Stages 2 - 4 (age 57.6 +/- 10.3 years, 62% male, 22% diabetics). CAC and vertebral bone density (VBD) were measured by computed tomography. Results: At baseline, 46% of the patients had CAC (calcified group) and calcification was not identified in 54% of the patients (non-calcified group). the calcified group was older, predominantly male, and had lower VBD in comparison to non-calcified group. CAC progression was observed only in the calcified group (91% of the patients increased calcium score). the multiple regression analysis revealed loss of VBD as the independent determinant of CAC progression in these patients. Conclusion: CAC progression was associated with loss of VBD in non-dialyzed CKD patients.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, Dept Internal Med, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Med Sch Hosp, Heart Inst InCor, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, Dept Internal Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent425-431
dc.identifierhttp://dx.doi.org/10.5414/CN107515
dc.identifier.citationClinical Nephrology. Deisenhofen-muenchen: Dustri-verlag Dr Karl Feistle, v. 78, n. 6, p. 425-431, 2012.
dc.identifier.doi10.5414/CN107515
dc.identifier.issn0301-0430
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35604
dc.identifier.wosWOS:000313401400001
dc.language.isoeng
dc.publisherDustri-verlag Dr Karl Feistle
dc.relation.ispartofClinical Nephrology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectnon-dialyzed chronic kidney diseaseen
dc.subjectcoronary artery calcificationen
dc.subjectbone densityen
dc.titleThe association between coronary artery calcification progression and loss of bone density in non-dialyzed CKD patientsen
dc.typeinfo:eu-repo/semantics/article
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