Repeated amygdala-kindled seizures induce ictal rebound tachycardia in rats

Página do item simplificado
dc.contributor.authorPansani, Aline Priscila [UNIFESP]
dc.contributor.authorColugnati, Diego Basile [UNIFESP]
dc.contributor.authorSchoorlemmer, Gerhardus Hermanus Maria [UNIFESP]
dc.contributor.authorSonoda, Eliza Yumi de Freitas [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.contributor.authorCravo, Sergio Luiz [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2016-01-24T14:17:20Z
dc.date.available2016-01-24T14:17:20Z
dc.date.issued2011-11-01
dc.description.abstractIt is thought that cardiovascular changes may contribute to sudden death in patients with epilepsy. To examine cardiovascular alterations that occur during epileptogenesis, we measured the heart rate of rats submitted to the electrical amygdala kindling model. Heart rate was recorded before, during, and after the induced seizures. Resting heart rate was increased in stages 1, 3, and 5 as compared with the unstimulated control condition. in the initial one third of the seizures, we observed bradycardia, which increased in intensity with increasing stage and was blocked by injecting methyl atropine. During stage 5 seizures, a rebound tachycardia was observed that also increased in intensity with increasing number of seizures. This study demonstrated the influence of seizure frequency on cardiac autonomic modulation, providing a basis for discussion of potential mechanisms that cause patients with epilepsy to die suddenly. (C) 2011 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol Neurosci, São Paulo, Brazil
dc.description.affiliationUniv Fed Goias, Dept Physiol Sci, Goiania, GO, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol Neurosci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent442-449
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2011.07.034
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 22, n. 3, p. 442-449, 2011.
dc.identifier.doi10.1016/j.yebeh.2011.07.034
dc.identifier.fileWOS000296826700006.pdf
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34162
dc.identifier.wosWOS:000296826700006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSudden unexpected death in epilepsyen
dc.subjectKindlingen
dc.subjectHeart rateen
dc.subjectSeizure frequencyen
dc.titleRepeated amygdala-kindled seizures induce ictal rebound tachycardia in ratsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000296826700006.pdf
Tamanho:
751.14 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos