In vitro activities of caspofungin, amphotericin B and azoles against Coccidioides posadasii strains from Northeast, Brazil

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dc.contributor.authorCordeiro, R. A.
dc.contributor.authorBrilhante, R. S. N.
dc.contributor.authorRocha, M. F. G.
dc.contributor.authorFechine, M. A. B.
dc.contributor.authorCosta, A. K. F.
dc.contributor.authorCamargo, Z. P. [UNIFESP]
dc.contributor.authorSidrim, J. J. C.
dc.contributor.institutionUniv Fed Ceara
dc.contributor.institutionUniv Estadual Ceara
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:38:16Z
dc.date.available2016-01-24T12:38:16Z
dc.date.issued2006-01-01
dc.description.abstractCoccidioidomycosis is a systemic infection caused by the soil-dwelling dimorphic fungi Coccidioides spp. the disease is endemic in semiarid Northeast Brazil, where it is caused by C. posadasii. the aim of this study was to perform antifungal susceptibility tests of clinical and environmental strains of C. posadasii from Northeast Brazil. the in vitro activities of caspofungin, amphotericin B and azoles against clinical and environment isolates of C. posadasii were determined in accordance with the NCLLS M-38P macrodilution method. the antifungal susceptibility analysis showed that all the strains of C. posadasii (n = 10) were sensitive to caspofungin (16 mu g/ml <= MIC <= 32 mu g/ml), amphotericin B (0.0625 mu g/ml <= MIC <= 0.125 mu g/ml), ketoconazole (0.039 mu g/ml <= MIC <= 0.156 mu g/ml), itraconazole (0.125 mu g/ml <= MIC <= 0.5 mu g/ml), fluconazole (3.125 mu g/ml <= MIC <= 6.25 mu g/ml), and voriconazole (0.125 mu g/ml). This study is the first description of in vitro antifungal susceptibility pattern of Brazilian strains of C. posadasii.en
dc.description.affiliationUniv Fed Ceara, Med Mycol Specialized Ctr, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Postgrad Program Med Sci, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Estadual Ceara, Dept Biol Sci, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Estadual Ceara, Postgrad Program Vet Sci, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Postgrad Program Med Clin, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Biol Sci, Fortaleza, Ceara, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent21-26
dc.identifierhttp://dx.doi.org/10.1007/s11046-005-0177-0
dc.identifier.citationMycopathologia. Dordrecht: Springer, v. 161, n. 1, p. 21-26, 2006.
dc.identifier.doi10.1007/s11046-005-0177-0
dc.identifier.issn0301-486X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28638
dc.identifier.wosWOS:000234397000003
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofMycopathologia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectantifungal susceptibility testingen
dc.subjectCoccidioides posadasiien
dc.subjectNortheast Brazilen
dc.titleIn vitro activities of caspofungin, amphotericin B and azoles against Coccidioides posadasii strains from Northeast, Brazilen
dc.typeinfo:eu-repo/semantics/article
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