GFR estimated from cystatin C versus creatinine in children born small for gestational age

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dc.contributor.authorFranco, Maria do Carmo Pinho [UNIFESP]
dc.contributor.authorNishida, Sonia Kiyomi [UNIFESP]
dc.contributor.authorSesso, Ricardo de Castro Cintra [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:27Z
dc.date.available2016-01-24T13:51:27Z
dc.date.issued2008-06-01
dc.description.abstractBackground: Low birth weight caused by intrauterine growth restriction may be a risk factor for renal impairment in the adult life.Study Design: A cross-sectional study.Setting & Participants: 71 children aged 8 to 13 years living in the community of São Paulo, Brazil, were included in the study. Gestational age was within the normal range.Predictors: Birth weight (range, 2,052 to 3,560 g) divided into quartiles: 2,500 g or less; 2,501 to 2,740 g; 2,741 to 3,000 g; and greater than 3,000 g. Birth weight ascertained by birth records in 43 and by recall in 28 participants.Outcomes & Measurements: Cystatin C, creatinine, and glomerular filtration rate (GFR) estimated by equations using cystatin C (eGFR(cys)) or creatinine (eGFR(cr)).Results: Overall, mean serum creatinine level was 0.8 +/- 0.01 (SE) mg/dL (range, 0.7 to 1.1 mg/dL); mean plasma cystatin C level was 0.9 +/- 0.02 mg/L (range, 0.5 to 1.6 mg/L), and eGFR(cr) and eGFR(cys) were 102.4 +/- 2.16 (range, 66 to 140) and 91.8 +/- 2.46 mL/min/1.73 m(2) (range, 49 to 139 mL/min/1.73 m(2)), respectively. No differences were found for serum creatinine or eGFR(cr) values among the birth-weight quartiles. There was a significant linear trend of increasing cystatin C levels (decreasing eGFR(cys) in the lower birth-weight quartile groups (P = 0.002 and P = 0.02, respectively). Systolic blood pressure correlated with plasma cystatin C level (r = 0.31; P = 0.008) and eGFR(cys) (r = -0.26; P = 0.028). Covariance analysis adjusting for age, sex, body mass index for age compared with standards of the National Center for Health Statistics and expressed as a z score, and systolic blood pressure showed that cystatin C values remained greater in the lowest than highest birth-weight quartile (1.01 +/- 0.05 versus 0.83 +/- 0.05 mg/L; P = 0.02).Limitations: Ascertainment of birth weight by recall in some participants. Lack of measurement of microalbuminuria, absence of direct GFR measurement, and small sample size.Conclusions: Lower birth weight is associated with higher levels of cystatin C but not creatinine in 8-13 yr. old children born full-term.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, Dept Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, Dept Med, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent925-932
dc.identifierhttps://dx.doi.org/10.1053/j.ajkd.2008.02.305
dc.identifier.citationAmerican Journal of Kidney Diseases. Philadelphia: W B Saunders Co-Elsevier Inc, v. 51, n. 6, p. 925-932, 2008.
dc.identifier.doi10.1053/j.ajkd.2008.02.305
dc.identifier.issn0272-6386
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/30712
dc.identifier.wosWOS:000256551700010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAmerican Journal of Kidney Diseases
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectIntrauterine growth restrictionen
dc.subjectCystatin Cen
dc.subjectGlomerular filtration rateen
dc.subjectBirth weighten
dc.titleGFR estimated from cystatin C versus creatinine in children born small for gestational ageen
dc.typeinfo:eu-repo/semantics/article
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