Deep brain stimulation of the inferior colliculus: A possible animal model to study paradoxical kinesia observed in some parkinsonian patients?

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dc.contributor.authorMelo-Thomas, Liana [UNIFESP]
dc.contributor.authorThomas, Uwe
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionINEC
dc.contributor.institutionUniv Marburg
dc.contributor.institutionThomas RECORDING GmbH
dc.date.accessioned2016-01-24T14:40:04Z
dc.date.available2016-01-24T14:40:04Z
dc.date.issued2015-02-15
dc.description.abstractThe inferior colliculus (IC) plays an important role in the normal processing of the acoustic message and is also involved in the filtering of acoustic stimuli of aversive nature. the neural substrate of the IC can also influence haloperidol-induced catalepsy. Considering that (i) paradoxical kinesia, observed in some parkinsonian patients, seems to be dependent of their emotional state and (ii) deep brain stimulation (DBS) represents an alternative therapeutic route for the relief of parkinsonian symptoms, the present study investigated the consequence of DBS at the IC on the catalepsy induced by haloperidol in rats. Additionally, we investigated if DBS of the IC can elicit motor responses in anesthetized rats and whether DBS elicits distinct neural firing patterns of activity at the dorsal cortex (DCIC) or central nucleus (CNIC) of the IC. A significant reduction of the catalepsy response was seen in rats previously given haloperidol and receiving DBS at the IC. in addition, electrical stimulation to the ventral part of the CNIC induced immediate motor responses in anesthetized rats. the neuronal spontaneous activity was higher at the ventral part of the CNIC than the dorsal part. DBS to the ventral part but not to the dorsal part of the CNIC increased the spike rate at neurons a few hundred microns away from the stimulation site. It is possible that the IC plays a role in the sensorimotor gating activated by emotional stimuli, and that DBS at the IC can be a promising new animal model to study paradoxical kinesia in rats. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationINEC, Inst Neurociencias & Comportamento, BR-14050220 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Marburg, D-35032 Marburg, Germany
dc.description.affiliationThomas RECORDING GmbH, D-35394 Giessen, Germany
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2011/01409-4
dc.format.extent1-8
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2014.10.035
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 279, p. 1-8, 2015.
dc.identifier.doi10.1016/j.bbr.2014.10.035
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38760
dc.identifier.wosWOS:000348255200001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectInferior colliculusen
dc.subjectParadoxical kinesiaen
dc.subjectCatalepsyen
dc.subjectDeep brain stimulationen
dc.subjectParkinson diseaseen
dc.subjectHaloperidolen
dc.titleDeep brain stimulation of the inferior colliculus: A possible animal model to study paradoxical kinesia observed in some parkinsonian patients?en
dc.typeinfo:eu-repo/semantics/article
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