Polymorphisms of estrogen receptor-alpha gene in Brazilian women with high breast density after menopause

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dc.contributor.authorSouza, Marilene Alicia
dc.contributor.authorFonseca, Angela Maggio
dc.contributor.authorBagnoli, Vicente R.
dc.contributor.authorBarros, Nestor de
dc.contributor.authorFranzolin, Solange O. B.
dc.contributor.authorCarvalho, Katia C.
dc.contributor.authorSoares Junior, José Maria [UNIFESP]
dc.contributor.authorBaracat, Edmund C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:32:07Z
dc.date.available2016-01-24T14:32:07Z
dc.date.issued2013-08-01
dc.description.abstractThe association of genetic polymorphism in the estrogen receptor alpha (ER alpha) gene and risk for diseases including breast cancer (BC) has been the subject of great interest.Objective: Checking on women with high breast density after menopause, the frequency of the Pvull and Xbal polymorphisms of the ER alpha gene and the correlation between them and the known risk factors for breast cancer.Method: Observational study with 308 women between 45 and 65 years old with high breast density, without hormonal therapy, menstruation for a year or more, breast and ovarian cancer history. It was characterized in clinical history and physical examination: menarche, menopause, parity, family history of BC, smoking, alcohol intake and body mass index.Results: the allelic and genotypic frequencies for ER alpha-Pvull and Xbal: p = 43.99%; p = 56.01%; pp = 32.14%; Pp = 47.73% and PP = 20.13%; X = 41.56%; x = 58.44%; xx = 33.44%; Xx = 50.00% and XX = 16.56%, respectively. the most frequent risk factors for BC: menarche before 12 years old (35.38%), nulliparity or first child after 28 years old (41.66%), family history of BC (19.16%) and overweight/obesity (62.01%).Conclusion: Allelic and genotypic distribution similar to literature. the risk factors for BC were more prevalent in women with high breast density but without significant associations with these polymorphisms.en
dc.description.affiliationUniv São Paulo, BR-17010250 Bauru, Brazil
dc.description.affiliationSão Paulo State Univ, Botucatu, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationHosp Clin São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Ginecologia, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2009/54563-0
dc.format.extent771-774
dc.identifierhttp://dx.doi.org/10.3109/09513590.2013.801438
dc.identifier.citationGynecological Endocrinology. New York: Informa Healthcare, v. 29, n. 8, p. 771-774, 2013.
dc.identifier.doi10.3109/09513590.2013.801438
dc.identifier.issn0951-3590
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36638
dc.identifier.wosWOS:000321211400009
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofGynecological Endocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectBreast neoplasmsen
dc.subjectestrogen receptorsen
dc.subjectgenetic polymorphismen
dc.subjectmammographyen
dc.subjectrisk factorsen
dc.titlePolymorphisms of estrogen receptor-alpha gene in Brazilian women with high breast density after menopauseen
dc.typeinfo:eu-repo/semantics/article
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