Organization of electrically and chemically evoked defensive behaviors within the deeper collicular layers as compared to the periaqueductal gray matter of the rat

Página do item simplificado
dc.contributor.authorBittencourt, A. S.
dc.contributor.authorNakamura-Palacios, E. M.
dc.contributor.authorMauad, H.
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSchenberg, L. C.
dc.contributor.institutionUniv Fed Espirito Santo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:34Z
dc.date.available2016-01-24T12:37:34Z
dc.date.issued2005-01-01
dc.description.abstractStimulation of the periaqueductal gray matter (PAG) and the deeper layers of superior colliculus (SC) produces both freezing (tense immobility) and flight (trotting, galloping and jumping) behaviors along With exophthalmus (fully opened bulging eyes) and, less often, micturition and defecation. the topography of these behaviors within the distinct layers of SC remains unclear. Therefore, this study compared the defensive repertoire of intermediate (ILSC) and deep (DLSC) layers of SC to those of dorsolateral periaqueductal gray matter (DLPAG) and lateral periaqueductal gray matter (LPAG) [Neuroscience 125 (2004) 71]. Electrical stimulation was carried out through intensity- (0-70 mu A) and frequency-varying (0-130 Hz) pulses. Chemical stimulation employed a slow microinfusion of N-methyl-D-aspartic acid (NMDA, 0-2.3 nmol, 0.5 nmol/min). Probability curves of intensity-, frequency- and NMDA-evoked behaviors, as well as the unbiased estimates of median stimuli, were obtained by threshold logistic analysis. Compared with the PAG, the most important differences were the lack of frequency-evoked jumping in both layers of SC and the lack of NMDA-evoked galloping in the ILSC. Moreover, although galloping and jumping were also elicited by NMDA stimulation of DLSC, effective doses were about three times higher than those of DLPAG, suggesting the spreading of the injectate to the latter structure. in contrast, exophthalmus, immobility and trotting were evoked throughout the tectum structures. However, whatever the response and kind of stimulus, the lowest thresholds were always found in the DLPAG and the highest ones in the ILSC. Besides, neither the appetitive, nor the offensive, muricide or male reproductive behaviors were produced by any kind of stimulus in the presence of appropriate targets. Accordingly, the present data suggest that the deeper layers of SC are most likely involved in the increased attentiveness (exophthalmus, immobility) or restlessness (trotting) behaviors that herald a full-blown flight reaction (galloping, jumping) mediated in the PAG. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.en
dc.description.affiliationUniv Fed Espirito Santo, Dept Ciencias Fisiol, Ctr Biomed, Edificio Programa Pos Grad Ciencias Fisiol, BR-29043125 Vitoria, ES, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent873-892
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2005.03.012
dc.identifier.citationNeuroscience. Oxford: Pergamon-Elsevier B.V., v. 133, n. 4, p. 873-892, 2005.
dc.identifier.doi10.1016/j.neuroscience.2005.03.012
dc.identifier.issn0306-4522
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28086
dc.identifier.wosWOS:000230268500002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectperiaqueductal gray matteren
dc.subjectsuperior colliculusen
dc.subjectdefenseen
dc.subjectflighten
dc.subjectfreezingen
dc.subjectN-methyl-d-aspartic aciden
dc.titleOrganization of electrically and chemically evoked defensive behaviors within the deeper collicular layers as compared to the periaqueductal gray matter of the raten
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Outras produções