The predictive value of serum laminin for the risk of variceal bleeding related to portal pressure levels
| dc.contributor.author | Kondo, M. | |
| dc.contributor.author | Miszputen, Sender Jankiel [UNIFESP] | |
| dc.contributor.author | LeiteMor, MBM | |
| dc.contributor.author | Parise, Edison Roberto [UNIFESP] | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2018-06-15T17:30:26Z | |
| dc.date.available | 2018-06-15T17:30:26Z | |
| dc.date.issued | 1995-09-01 | |
| dc.description.abstract | Background/Aims: This paper presents the results of the radioimmunologic determination of laminin, in serum of patients with alcoholic liver cirrhosis with a preserved hepatic function, trying to evaluate its predictive value for the risk of variceal bleeding, assessed by a portal pressure level equal to or higher than 12 mmHg (7).Patients and Methods: Twenty alcoholic cirrhotic patients with a preserved hepatic function as assessed by the Child-Pugh classification, had their peripheral blood taken for radioimmunological determination of serum laminin and were submitted to hepatic vein catheterization, for portal pressure measurement.Results: A positive and significant correlation (r=0.70, p<0.001) was found between serum laminin Levels (mean value+SD=2.70+1.13 U/ml) and hepatic vein pressure gradient (mean HVPG+SD=16.30+6.06 mmHg). Such correlation prompted us to find a value for the level of laminin that more closely represented a HVPG of 12 mmHg, a well known threshold pressure for esophageal varices bleeding. At a cut-off concentration, for laminin of 2.19 U/ml, sensitivity was 73%, specificity 60%, the positive predictive value was 85% and the negative predictive value 43%. In this study population with a prevalence of 75% of a HVPG greater than or equal to 12 mmHg, the diagnostic accuracy for such levels of serum laminin was 70%.Conclusions: Although a valid attempt in having a hypertension, peripheral serum laminin alone doesn't hypertension and to assess the risk of variceal bleeding in patients with alcoholic cirrhosis. | en |
| dc.description.affiliation | ESCOLA PAULISTA MED,GASTROENTEROL SECT,BR-04023000 SAO PAULO,BRAZIL | |
| dc.description.affiliationUnifesp | ESCOLA PAULISTA MED,GASTROENTEROL SECT,BR-04023000 SAO PAULO,BRAZIL | |
| dc.description.source | Web of Science | |
| dc.format.extent | 542-545 | |
| dc.identifier.citation | Hepato-gastroenterology. Athens: H G E Update Medical Publ Ltd., v. 42, n. 5, p. 542-545, 1995. | |
| dc.identifier.issn | 0172-6390 | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/43769 | |
| dc.identifier.wos | WOS:A1995TK84700021 | |
| dc.language.iso | eng | |
| dc.publisher | H G E Update Medical Publ Ltd. | |
| dc.relation.ispartof | Hepato-gastroenterology | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.subject | laminin | en |
| dc.subject | portal hypertension | en |
| dc.subject | hepatic cirrhosis | en |
| dc.title | The predictive value of serum laminin for the risk of variceal bleeding related to portal pressure levels | en |
| dc.type | info:eu-repo/semantics/article |