Repurposing of anti-diabetic agents for the treatment of cognitive impairment and mood disorders

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dc.contributor.authorCha, D. S.
dc.contributor.authorVahtra, M.
dc.contributor.authorAhmed, J.
dc.contributor.authorKudlow, P. A.
dc.contributor.authorMansur, R. B. [UNIFESP]
dc.contributor.authorCarvalho, A. F.
dc.contributor.authorMcIntyre, R. S.
dc.date.accessioned2019-01-21T10:29:51Z
dc.date.available2019-01-21T10:29:51Z
dc.date.issued2016
dc.description.abstractImpairments in cognitive function represent a consistent, non-specific, and clinically significant feature in metabolic, mood, and dementing disorders. The foregoing observation is instantiated by evidence demonstrating that these disorders share pathophysiological mechanisms including, but not limited to, aberrant insulin signaling, inflammation, and glucocorticoid activity. Moreover, these mechanisms have been consistently reported to increase vulnerability to and/or exacerbate impairments in cognitive function. Notwithstanding evidence suggesting a bidirectional relationship between disturbances in the metabolic milieu, mood, and increased risk for dementia, efficacious treatments that target cognitive impairments in these populations do not presently exist. Taken together, it is proposed that anti-diabetic agents may aid the management of mood disorders and future risk for dementia through disease modification by targeting underlying pathophysiological mechanisms (e.g., aberrant metabolic function) rather than focusing solely on symptom mitigation. The current aim is to provide a brief narrative review of extant studies that report on the potential neurotherapeutic effects of anti-diabetic agents on disturbances in mood and impairments in cognitive function.en
dc.description.affiliationUniv Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Inst Med Sci, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Arts & Sci, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Dept Psychiat, Clinician Scientist Program, Psychiat Resident, Toronto, ON, Canada
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, LINC, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Program Recognit & Intervent Individuals Risk Men, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Clin Med, Fac Med, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Translat Psychiat Res Grp, Fac Med, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Toronto, Dept Psychiat, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Dept Pharmacol, Toronto, ON, Canada
dc.description.affiliationUniv Hlth Network, Toronto, ON M5T 2S8, Canada
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, LINC, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, Program Recognit & Intervent Individuals Risk Men, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent465-473
dc.identifierhttp://dx.doi.org/10.2174/1566524016666160429121737
dc.identifier.citationCurrent Molecular Medicine. Sharjah, v. 16, n. 5, p. 465-473, 2016.
dc.identifier.doi10.2174/1566524016666160429121737
dc.identifier.issn1566-5240
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49431
dc.identifier.wosWOS:000382639700004
dc.language.isoeng
dc.publisherAssoc Brasil Polimeros
dc.relation.ispartofCurrent Molecular Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDepressionen
dc.subjectBipolaren
dc.subjectDiabetesen
dc.subjectDementiaen
dc.subjectAlzheimer's Diseaseen
dc.subjectInsulinen
dc.subjectInsulin Resistanceen
dc.subjectGlp-1en
dc.subjectIncretinen
dc.subjectThiazolidinedioneen
dc.subjectMetforminen
dc.subjectCognitionMajor Depressive Disorderen
dc.subjectActivated Protein-Kinaseen
dc.subjectGlucagon-Like Peptide-1en
dc.subjectCentral-Nervous-Systemen
dc.subjectBlood-Brain-Barrieren
dc.subjectHigh-Fat-Dieten
dc.subjectType-2 Diabetes-Mellitusen
dc.subjectPpar-Gamma Ligandsen
dc.subjectAlzheimers-Diseaseen
dc.subjectInsulin-Resistanceen
dc.titleRepurposing of anti-diabetic agents for the treatment of cognitive impairment and mood disordersen
dc.typeinfo:eu-repo/semantics/article
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