Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection

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dc.contributor.authorAggio, Fabio Bom [UNIFESP]
dc.contributor.authorFarah, M. E.
dc.contributor.authorMelo, G. B. de
dc.contributor.authord'Azevedo, P. A.
dc.contributor.authorPignatri, A. C. C.
dc.contributor.authorHofling-Lima, A. L.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:57Z
dc.date.available2016-01-24T12:41:57Z
dc.date.issued2007-03-01
dc.description.abstractPurpose: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.Methods: Two patients with exudative age-related macular degeneration were treated sequentially with an intravitreal injection of bevacizumab and developed signs of severe but painless infectious endophthalmitis 2 days later. Vitreous samples were obtained, followed by the injection of vancomycin 1 mg/0.1 ml and ceftazidime 2.25 mg/0.1 ml. Pulsed-field gel electrophoresis (PFGE) was used to determine whether the isolated microorganisms were the same.Results: Coagulase-negative staphylococci were identified and isolated from the vitreous specimen of both patients. PFGE revealed different patterns of banding, excluding that interpatient contamination occured.Conclusions: Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection.en
dc.description.affiliationUniversidade Federal de São Paulo, Vis Inst, BR-01239010 São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Special Lab Clin Microbiol, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Vis Inst, BR-01239010 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Special Lab Clin Microbiol, Div Infect Dis, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent408-409
dc.identifierhttp://dx.doi.org/10.1038/sj.eye.6702683
dc.identifier.citationEye. London: Nature Publishing Group, v. 21, n. 3, p. 408-409, 2007.
dc.identifier.doi10.1038/sj.eye.6702683
dc.identifier.issn0950-222X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29573
dc.identifier.wosWOS:000244604900018
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofEye
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectintravitreal bevacizumaben
dc.subjectendophthalmitisen
dc.subjectocular inflammationen
dc.subjectVEGFen
dc.titleAcute endophthalmitis following intravitreal bevacizumab (Avastin) injectionen
dc.typeinfo:eu-repo/semantics/article
unifesp.campusEscola Paulista de Medicina (EPM)pt
unifesp.departamentoOftalmologia
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