Preserved white matter in unmedicated pediatric bipolar disorder

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dc.contributor.authorTeixeira, Ana Maria Aristimunho
dc.contributor.authorKleinman, Ana
dc.contributor.authorZanetti, Marcus
dc.contributor.authorJackowski, Marcel [UNIFESP]
dc.contributor.authorDuran, Fábio Luís de Souza
dc.contributor.authorPereira, Fabricio
dc.contributor.authorLafer, Beny
dc.contributor.authorBusatto Filho, Geraldo [UNIFESP]
dc.contributor.authorCaetano, Sheila Cavalcante
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:51Z
dc.date.available2016-01-24T14:37:51Z
dc.date.issued2014-09-05
dc.description.abstractWhite matter (WM) abnormalities have been reported in bipolar disorder (BD) patients, as well as in their non-BD relatives, both children and adults. Although it is considered an emerging vulnerability marker for BD, there are no studies investigating WM alterations in pediatric unmedicated patients and young healthy offspring. in this study, we evaluated the presence of WM alterations in 18 pediatric, non medicated BD patients, as well as in 18 healthy offspring of BD type I parents and 20 healthy controls. 3T DT-MRI data were acquired and scans were processed with tract-based spatial statistics to provide measures of fractional anisotropy and diffusivity. We found no significant differences in WM microstructure between BD patients, healthy offspring and healthy controls. Previous studies that reported WM alterations investigated older subjects, either on medication (BD patients) or with psychiatric diagnoses other than BD (unaffected offspring). Our findings highlight the importance of the understanding of disease ontogeny and brain development dynamics in the search for early vulnerability markers for psychiatric disorders. (C) 2014 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv São Paulo, Sch Med, Dept Psychiat, Bipolar Res Program, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Psychiat, Lab Psychiat Neuroimaging, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Ctr Support Res Appl Neurosci, São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent41-45
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2014.06.061
dc.identifier.citationNeuroscience Letters. Clare: Elsevier B.V., v. 579, p. 41-45, 2014.
dc.identifier.doi10.1016/j.neulet.2014.06.061
dc.identifier.fileWOS000341482100008.pdf
dc.identifier.issn0304-3940
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38207
dc.identifier.wosWOS:000341482100008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectBipolar disorderen
dc.subjectChildrenen
dc.subjectDT-MRIen
dc.subjectWhite matteren
dc.subjectOffspringen
dc.titlePreserved white matter in unmedicated pediatric bipolar disorderen
dc.typeinfo:eu-repo/semantics/article
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