pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers

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dc.contributor.authorLima, Thamires Marques de
dc.contributor.authorKazama, Cristiane Mayumi
dc.contributor.authorKoczulla, Andreas Rembert
dc.contributor.authorHiemstra, Pieter S.
dc.contributor.authorMacchione, Mariangela
dc.contributor.authorFernandes, Ana Luisa Godoy [UNIFESP]
dc.contributor.authorSantos, Ubiratan de Paula
dc.contributor.authorBueno-Garcia, Maria Lucia
dc.contributor.authorZanetta, Dirce Maria
dc.contributor.authorAndre, Carmen Diva Saldiva
dc.contributor.authorSaldiva, Paulo Hilário Nascimento
dc.contributor.authorNakagawa, Naomi Kondo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionPhilipps University
dc.contributor.institutionLeiden University Medical Center
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInstituto do Coração
dc.date.accessioned2015-06-14T13:45:43Z
dc.date.available2015-06-14T13:45:43Z
dc.date.issued2013-12-01
dc.description.abstractOBJECTIVE: To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers related to air pollution. METHODS: A total of 87 male, non-smoking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in exhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study). RESULTS: Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values were lower in traffic-controllers (7.80 and 7.30, respectively). Both groups presented similar cytokines concentrations in both substrates, however, IL-1β and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration was greater at the workplace of traffic-controllers compared with that of office-workers. CONCLUSION: The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers.en
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Department of Pathology
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Department of Physiotherapy
dc.description.affiliationPhilipps University Department of Pulmonology
dc.description.affiliationLeiden University Medical Center Department of Pulmonology
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) School of Medicine Department of Pneumology
dc.description.affiliationPneumology Division Pneumology Division
dc.description.affiliationInstituto do Coracao Instituto do Coracao
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Department of Internal Medicine
dc.description.affiliationUniversidade de São Paulo Public Health Faculty Department of Epidemiology
dc.description.affiliationUniversidade de São Paulo Institute of Mathematics and Statistics
dc.description.affiliationUnifespUNIFESP, School of Medicine Department of Pneumology
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 07/51605-9
dc.description.sponsorshipIDFAPESP: 09/50056-7
dc.description.sponsorshipIDCNPq: 555.223/06-0
dc.format.extent1488-1494
dc.identifierhttp://dx.doi.org/10.6061/clinics/2013(12)03
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 68, n. 12, p. 1488-1494, 2013.
dc.identifier.doi10.6061/clinics/2013(12)03
dc.identifier.fileS1807-59322013001201488.pdf
dc.identifier.issn1807-5932
dc.identifier.issn1980-5322
dc.identifier.scieloS1807-59322013001201488
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/8060
dc.identifier.wosWOS:000329985900003
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectExhaled Breath Condensateen
dc.subjectNasal Lavage Fluiden
dc.subjectAir Pollutionen
dc.subjectAirway Inflammationen
dc.titlepH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workersen
dc.typeinfo:eu-repo/semantics/article
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