Acerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet

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dc.contributor.authorDias, Fernando Milanez
dc.contributor.authorLeffa, Daniela Dimer
dc.contributor.authorDaumann, Francine
dc.contributor.authorMarques, Scherolin de Oliveira
dc.contributor.authorLuciano, Thais F.
dc.contributor.authorPossato, Jonathan Correa
dc.contributor.authorSantana, Aline Alves de [UNIFESP]
dc.contributor.authorNeves, Rodrigo Xavier
dc.contributor.authorRosa, Jose Cesar
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorRodrigues, Bruno
dc.contributor.authorAndrade, Vanessa Moraes de
dc.contributor.authorSouza, Claudio Teodoro de
dc.contributor.authorLira, Fabio Santos de [UNIFESP]
dc.contributor.institutionUniv Extremo Sul Catarinense
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Sao Judas Tadeu
dc.contributor.institutionUniv Estadual Paulista
dc.date.accessioned2016-01-24T14:35:18Z
dc.date.available2016-01-24T14:35:18Z
dc.date.issued2014-02-04
dc.description.abstractBackground: Obesity has been studied as a metabolic and an inflammatory disease and is characterized by increases in the production of pro-inflammatory adipokines in the adipose tissue. To elucidate the effects of natural dietary components on the inflammatory and metabolic consequences of obesity, we examined the effects of unripe, ripe and industrial acerola juice (Malpighia emarginata DC.) on the relevant inflammatory and lipolysis proteins in the adipose tissue of mice with cafeteria diet-induced obesity.Materials/methods: Two groups of male Swiss mice were fed on a standard diet (STA) or a cafeteria diet (CAF) for 13 weeks. Afterwards, the CAF-fed animals were divided into five subgroups, each of which received a different supplement for one further month (water, unripe acerola juice, ripe acerola juice, industrial acerola juice, or vitamin C) by gavage. Enzyme-linked immunosorbent assays, Western blotting, a colorimetric method and histology were utilized to assess the observed data.Results: the CAF water (control obese) group showed a significant increase in their adiposity indices and triacylglycerol levels, in addition to a reduced IL-10/TNF-alpha ratio in the adipose tissue, compared with the control lean group. in contrast, acerola juice and Vitamin C intake ameliorated the weight gain, reducing the TAG levels and increasing the IL-10/TNF-alpha ratio in adipose tissue. in addition, acerola juice intake led to reductions both in the level of phosphorylated JNK and to increases in the phosphorylation of I kappa B alpha and HSLser660 in adipose tissue.Conclusions: Taken together, these results suggest that acerola juice reduces low-grade inflammation and ameliorates obesity-associated defects in the lipolytic processes.en
dc.description.affiliationUniv Extremo Sul Catarinense, Lab Mol & Cellular Biol, Grad Programme Hlth Sci, Dept Hlth Sci,UNESC, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliationUniv Extremo Sul Catarinense, Lab Exercise Biochem & Physiol, Grad Programme Hlth Sci, Dept Hlth Sci,UNESC, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Fisiol, Disciplina Fisiol Nutr, BR-04023060 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Canc Metab Res Grp, Inst Biomed Sci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Immunometab Res Grp, Inst Biomed Sci, São Paulo, Brazil
dc.description.affiliationUniv Sao Judas Tadeu, Lab Movimento Humano, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Immunometab Res Grp, Dept Phys Educ, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Fisiol, Disciplina Fisiol Nutr, BR-04023060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1186/1476-511X-13-24
dc.identifier.citationLipids in Health and Disease. London: Biomed Central Ltd, v. 13, 9 p., 2014.
dc.identifier.doi10.1186/1476-511X-13-24
dc.identifier.fileWOS000333647100001.pdf
dc.identifier.issn1476-511X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37427
dc.identifier.wosWOS:000333647100001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofLipids in Health and Disease
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCafeteria dieten
dc.subjectMalpighia emarginata DCen
dc.subjectAdipose tissueen
dc.subjectInflammationen
dc.subjectLipolysisen
dc.titleAcerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria dieten
dc.typeinfo:eu-repo/semantics/article
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