Induction of neoplastic cells in rat skin

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dc.contributor.authorKorinfsky, Juliana Pedrosa
dc.contributor.authorPlapler, Helio [UNIFESP]
dc.contributor.authorMoreno, Tania Rita
dc.contributor.authorSantos, Itamar
dc.contributor.authorMaria, Celeste
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUNIVASF Department of Medicine
dc.contributor.institutionOswaldo Cruz Foundation
dc.date.accessioned2015-06-14T13:46:55Z
dc.date.available2015-06-14T13:46:55Z
dc.date.issued2014-02-01
dc.description.abstractPURPOSE:To investigate the induction of neoplastic lesions under the action of ultraviolet B radiation (UVR-B) and dimethyl benzanthracene (DMBA).METHODS:Forty Wistar rats were assigned to four groups (ten animals each), according to the procedure: group A received UVR-B irradiation, group B received topic DMBA, group C, UVR-B+DMBA and group D as control, observed for ten weeks. In the tenth week they went through a skin biopsy and histopathological study. The average thickness of the epidermis was calculated and evaluated statistically.RESULTS:Macroscopic lesions in group B were more of inflammatory kind compared to group A. Group C presented more injuries with neoplastic features than the others (p<0.01). Histologically there was a significant increase in thickness of the epidermis of all groups compared to control, however the greatest thickness measures occurred in Group C (p<0.01).CONCLUSIONS:The population exposed to ultraviolet B radiation is subject to suffer skin lesions that can develop into cancer. The association with hydrocarbons as the dimethyl benzanthracene increases the possibility of malignancy. May not be clinically evident determine when a solar keratosis ends and when a CEC begins. For this reason, histological study associated with health education prompting the early and irreversible injury prevention is necessary.en
dc.description.affiliationSão Paulo Federal University
dc.description.affiliationUNIFESP Paulista Medical School Department of Surgery
dc.description.affiliationUNIVASF Department of Medicine
dc.description.affiliationOswaldo Cruz Foundation
dc.description.affiliationUnifespSão Paulo Federal University
dc.description.affiliationUnifespUNIFESP, Paulista Medical School Department of Surgery
dc.description.sourceSciELO
dc.format.extent104-110
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502014000200006
dc.identifier.citationActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, n. 2, p. 104-110, 2014.
dc.identifier.doi10.1590/S0102-86502014000200006
dc.identifier.fileS0102-86502014000200104.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502014000200104
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/8224
dc.identifier.wosWOS:000333046900006
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject9,10-Dimethyl-1,2-benzanthraceneen
dc.subjectEpidermisen
dc.subjectSolar Radiationen
dc.subjectSkin Neoplasmsen
dc.subjectRatsen
dc.titleInduction of neoplastic cells in rat skinen
dc.typeinfo:eu-repo/semantics/article
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