Navegando por Palavras-chave "Chia"

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    Caracterização da mucilagem de sementes de chia para potencial uso em oftalmologia
    (Universidade Federal de São Paulo (UNIFESP), 2017-04-28) Ragazzi, Raul Diniz [UNIFESP]; Freitas, Denise De [UNIFESP]; http://lattes.cnpq.br/4036480252471491; http://lattes.cnpq.br/9562636211510007; Universidade Federal de São Paulo (UNIFESP)
    Having in view its viscosity, obtained from the mucilage, a very low toxicity and their physico-chemical characteristics, it was noticed that the use of possible vehicles for ophthalmological use of drugs could be taken into account, knowing that in ophthalmology, the use of viscous products - particularly topical - has great value at time of contact with the ocular surface. In this sense, the present study deals with the development of a method for characterization and analysis. Its use as a vehicle of oral medications is also widely known as bases for syrups and laxatives, due to the property to provide an indigestible residue, to increase fecal bulk and stimulate peristalsis The mucilage found in the seeds of chia it is a source of fatty acids, omega 3, antioxidants, proteins, vitamins, minerals and dietary fiber. When these dry seeds are added to water, a highly viscous solution is generated due to the release of mucilage and high molecular weight carbohydrates, with wide application in food industry and pharmaceuticals. This project was conceived on the basis of the characterization and analysis of extracted mucilage chia seed (Salvia hispanica L.). Toxicity tests, eye irritation and corrosion properties were assessed for the safety of the product, which also underwent an analysis for its characterization, demonstrating their structural and functional characteristics. In tests no toxicity, irritability or corrosion properties and its characterization and structural and functional characteristics was demonstrated. For the first time was evaluated chia seed for possible use in ophthalmology. The toxicity studies, irritability and corrosion properties as well as characterization of the product were consensus and consistent with the literature. It has been shown by the tests mentioned above that chia has great potential for use in ophthalmology.
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    Chia (Salvia hispanica L.) flour promotes beneficial effects on adipose tissue but not on glycaemic profile of diet-induced obesity in mice
    (Wiley, 2017) Carnier, June [UNIFESP]; Silva, Fernanda Pinheiro da [UNIFESP]; Miranda, Danielle Araujo de [UNIFESP]; Santamarina, Aline Boveto [UNIFESP]; Mennitti, Lais Vales [UNIFESP]; Moreira, Renata Guimaraes; Nascimento, Claudia Maria da Penha Oller do [UNIFESP]; Ribeiro, Eliane Beraldi [UNIFESP]; Oyama, Lila Missae [UNIFESP]
    This study evaluated effects of integral chia flour (Salvia hispanica L.) associated with high‐fat diet on glucose metabolism, fatty acid profile, and inflammatory mediators in epididymal adipose and liver tissue using experimental obesity models induced by high‐calorie and ‐fat diets. Forty‐eight mice were divided into four experimental groups: control diet (C); control diet + chia flour (CCh); high‐fat and ‐calorie diet (H), and high‐fat and ‐calorie diet + chia flour (HCh). Tissue cytokines, fatty acid profile, and glycaemic profile were measured. In oral glucose tolerance testing, HCh presented higher glycaemia than H at 15, 30, and 120 min. In epididymal adipose tissue, CCh showed higher accumulation of alpha‐linolenic fatty acid (α‐LNA) than C, while HCh showed higher accumulation of α‐LNA and lower concentrations of C20:4n6 fatty acid than H. In liver tissue, CCh presented higher accumulation of α‐LNA and lower concentrations of C20:4n6 fatty acid than C. We believe that 12 g of chia flour per kg of food for 10 wk is essential for prevention and treatment of obesity; however, it may be necessary to adjust chia amounts and treatment times to improve glycaemic profiles. This study provides pioneering results on the effects of chia in mice. Practical applications: With the hope of losing weight and becoming healthier, many people adopt radical diets that can be harmful to their health. Accordingly, dietary guidelines must be carefully planned by qualified health professionals, especially considering the comorbidities of diabetes and cardiovascular disease that accompany obesity. In addition, the adequate treatment of obesity increases the chances of the patients maintaining their diet and lifestyle changes, thus, allowing for greater control of their obesity. Consequently, knowledge of the appropriate dosages and effects of chia is important for the development of new tools for composing dietary guidelines for healthy individuals, especially for the treatment of obese patients.
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    Efeito Da Chia ( Salvia Hispanica L) Sobre Parâmetros Metabólicos E Inflamatórios No Diabetes Mellitus, Em Camundongos
    (Universidade Federal de São Paulo (UNIFESP), 2017-11-30) Oliveira, Cinthia Romeika De [UNIFESP]; Silveira, Vera Lucia Flor [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction and Objectives: Diabetes mellitus (DM) is a chronic disease, characterized by hyperglycemia, which may be caused by the absence or deficient of insulin secretion or peripheral resistance to this hormone. As a consequence of this alteration, the adipose tissue of individuals with type 2 DM (DM2), presents high rates of lipolysis, aggravating the existing insulin resistance. Several studies have shown the importance of omega-3 polyunsaturated fatty acids (PUFAs w-3) as complementary therapy in the treatment of chronic diseases, including DM. Studies have shown that these PUFA decrease the inflammatory process and may improve insulin resistance. chia seeds, which has the vegetable oil with the highest concentration of PUFAs w-3, known until now, has been widely used by the population for reduction of weight, cholesterol and triglyceride, and also prevention of diabetes and cardiovascular diseases. However, the scientific papers which study these relations are few and still quite contradictory. This study aims to analyze the preventive effect of dietary supplementation with chia oil on metabolic and inflammatory parameters in mice submitted to the DM2 model, induced by hyperlipidic diet and streptozotocin (STZ). For this, we used male C57bl / 6 mice, divided into three groups: control (C), diabetic (D) and diabetic treated with chia (DC). The animals in group C received a normolipidic diet for 6 weeks and the animals in groups D and DC received a hyperlipidic diet and daily doses of water (D) or chia oil (DC). At the end of the third week of feeding, animals in groups D and DC were induced to partial insulin deficiency by 1 dose (45mg / kg) of STZ during 5 consecutive days. At the end of the sixth week the mice were euthanized, blood, liver and adipose tissues removed. Results and Conclusions: Preventive treatment with chia oil promoted beneficial effects such as decrease body mass gain without modifying caloric and energy consumption, reduction of visceral fat, lipolysis and adipocyte volume of the epididymal tissue and increase of HDL- c. However, although this treatment partially improved glucose tolerance, it did not improve insulin resistance. It appears that the beneficial effects induced by chia in lipid metabolism were not sufficient for the improvement of insulin resistance required for the treatment of DM2.
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    Efeito da ingestão da farinha da semente de chia (Salvia Hispanica L) no cólon intestinal de camundongos obesos
    (Universidade Federal de São Paulo (UNIFESP), 2017-08-31) Miranda, Danielle Araujo de [UNIFESP]; Oyama, Lila Missae [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Obesity has been considered a public health issue worldwide, in which the main causes are the intake of a hypercaloric diet as well as sedentarism. It is often associated with with several other diseases such as insulin resistance, type 2 diabetes mellitus, non-alcoholic fatty liver disease and cardiovascular diseases. Increased intestinal permeability may favor endotoxemia generated by lipopolysaccharide, a substance present in the cell membrane of Gram-negative bacteria, and consequently an increase in systemic inflammation and metabolic diseases. On the other hand, the consumption of a healthy diet can help in the prevention and treatment of the metabolic syndrome. In this way, the chia seed (Salvia hispánica L.), rich in polyunsaturated fatty acids, may present an anti-inflammatory role. In addition, chia is rich in antioxidants like caffeic acid and gallic acid, fiber and minerals. However, there are few studies involving chia seed, inflammatory mechanisms and intestinal permeability. Thus, the objective of this study was to analyze the effects of chia administration on intestinal permeability in obese mice. Swiss mice were treated with a hyperlipidic diet associated or not with supplementation with 3% chia flour for 16 weeks. We analyzed the metabolic profile, such as serum triglyceride, cholesterol, HDL-cholesterol, glucose tolerance test, antioxidant enzyme activity and the quantification of inflammatory pathways and tight junctions of the intestinal colon. The results show that a hyperlipidic diet intake promoted an increase of the mesenteric white adipose tissue weight and in glucose intolerance, and a decrease in the activity of hepatic catalase and the amount of occludin in the intestinal colon. Supplementation with 3% of chia flour was not efficient in decreasing the deleterious effects of lipid-rich dietary intake. In addition, supplementation with chia worsened glucose intolerance in animals receiving a hyperlipidic diet whereas in animals receiving a control diet, supplementation decreased the amount of occludin in the intestinal colon. In conclusion, the beneficial effects of chia seems to be dependent of the quantity how It is offered, since our data are conflicting with those of the literature, however, it is important to note that most of the studies, unlike our protocol, used chia in the form of seed or oil, and not the flour.
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    Efeito Da Suplementação Alimentar Com Farinha De Chia (Salvia Hispanica L) Noprocesso Inflamatórioe Desenvolvimento Tumoral Em Ratos Wistar Inoculados Com Tumor De Walker 256
    (Universidade Federal de São Paulo (UNIFESP), 2017-08-31) Carnier, Marcela [UNIFESP]; Oyama, Lila Missae [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Chia (Salvia hispanica L.) seeds contain large amounts of n-3 α-linolenic acid (ALA) and have been associated with many health benefits. The objective of the present study was to evaluate the effect of the diet throughout life, supplemented with chia flour in the development of cancer cachexia and inflammatory tissue response. Wistar rats at 30 days of age were treated with control diet or diet supplemented with chia flour for 8 weeks. After this period, a portion of the animals were inoculated with Walker 256 tumor cells. On the fourteenth day after tumor inoculation, the animals were euthanized and deposits of white adipose tissue, liver, gastrocnemius muscle and tumor were removed. Tumor weight increased and IL-10 content decreased in the group supplemented with chia flour. The presence of the tumor did not modify the cytokine content in the adipose tissues retroperitoneal and epididimal and gastrocnemius muscle. However, it decreased the protein content of IL-1β and TNF-α in the liver and IL-6R and IL-10R in mesenteric adipose tissue. In conclusion, our results demonstrated that supplementation with chia flour did not prevent the effects resulting from inoculation and tumor development in the Walker 256 model.
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    Métodos extrativos de mucilagem de semente de chia (Sálvia hispânica) para potencial uso em oftalmologia
    (Universidade Federal de São Paulo (UNIFESP), 2017-02-24) Gusmão, Roberto da Silva [UNIFESP]; Freitas, Denise de [UNIFESP]; http://lattes.cnpq.br/4036480252471491; http://lattes.cnpq.br/2908921235955460; Universidade Federal de São Paulo (UNIFESP)
    The mucilage are substances obtained some seeds, such as flax, chia, flax etc. These substances are rich in polysaccharides of high molecular weight and have essential oils, fatty acids and fiber. In oriental medicine, for example, chia seed has been used in various treatments. Among the treatments that chia seed is used in the control of cholesterol, obesity, food detoxification, increased gastric motility, reduction of cardiovascular risk, helps prevent premature aging and other benefits that are advocated in several published articles. The mucilage of plant origin are already established worldwide, mainly as vehicle laxative drugs. Thinking about the potential presented by the miraculous seed chia, the focus of this study is related to the choice of a cheap method of mucilage that produces seed with practical methods. It will be addressed in this work not only extractive methods for obtaining mucilage of chia seeds but will also be carried out physicochemical analyzes of mucilage obtained in the extraction process. Among the physicochemical studies in mucilage obtained include: pH, conductivity, sterility, heat resistance, osmolarity, viscosity and content, making it always the comparison with vehicles available in the market. Understand the physical and chemical characteristics of mucilage extracted from the seeds analyzed and understand its compatibility with the human body for potential use in medicine and especially in ophthalmology and the fundamental basis of this work.
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    Microcápsulas por coacervação complexa: avaliação do polissacarídeo de chia e proteínas vegetais como materiais de parede
    (Universidade Federal de São Paulo (UNIFESP), 2020-02-20) Silva, Leticia Ascendino [UNIFESP]; Bonsanto, Fabiana Perrechil [UNIFESP]; Universidade Federal de São Paulo
    The complex coacervates formed from biopolymers such as proteins and polysaccharides have received increasing attention due to their characteristics of biodegradability, biocompatibility, non-toxicity and low cost. The present work developed and evaluated microcapsules with hydrophobic core, obtained by complex coacervation, from the interaction of emulsions that were stabilized by rice protein (RP) or pea protein (PP) with chia polysaccharide (CP). These pairs are unpublished on the literature and emerge as an alternative to materials from animal sources, once they can be used by vegan and vegetarian consumers. The use of gelatin (GE) and arabic gum (AG) as model compounds was also evaluated. CP are not found commercially, therefore this extraction was necessary. It was extracted at room temperature, without using organic solvents. Different conditions of extraction were evaluated. The yield (Y) varied around 3% with a maximum of 4,8% for a 6 h extraction. The majority centesimal composition was carbohydrates (75%) and proteins (19%). About 85% of the analyzed monosaccharides were arabinose and xylose. The degradation of the polysaccharides occurs at temperatures above 250 ° C and the application of ultrasound increases the thermal stability of the extracted product. FTIR analyzes indicate that there was no change in the functional groups of the obtained polysaccharides. The net charge of the extracts is negative in the highest studied pH range, with pKa around 1.7. The samples showed a weak gel behavior with pseudoplastic characteristics. The polysaccharide sample with the highest Y was chosen for the microencapsulation stage. Zeta potential, turbidity and macroscopic appearance analyzes were used to determine the best ratio and the best pH of interaction between each pair of biopolymers. The ratios 01:01 and pH 2.5 for RP:AG, 01:02 for PP:AG and pH 2.5, 03:01 and pH 2.0 for RP:CP, 03:01 and pH 2.5 for PP:CP and 03:01 and pH 4.0 for GE:CP were evaluated. In all tested conditions, microparticles were formed with the average diameter varied from 22 to 53 µm. The Y for microparticles containing CP were higher (Y> 74%) than those containing AG (Y <40%) indicating that CP interacts better than AG with the proteins studied under the analyzed conditions. For the PP: AG system, the encapsulation efficiency was 9%, for the other studied systems it varied from 55% to 99%, showing a high potential for oil incorporation. The RP:CP system has lower R and EE, but higher when compared to PP:CP and GE:CP . PP:CP behaves similarly to GE:CP, which can replace GE on systems that contain CP.