Navegando por Palavras-chave "Consumo De Antibióticos"

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    Perfil de consumo de antibacterianos e correlação com multirresistência de bactérias isoladas em unidades críticas de um hospital de ensino de São Paulo
    (Universidade Federal de São Paulo (UNIFESP), 2021) Rattes, Alysson Leandro Ribeiro [UNIFESP]; Burattini, Marcelo Nascimento [UNIFESP]; Universidade Federal de São Paulo
    The evolution of multi resistance bacteria, resulting from selection pressure related to the inappropriate use of antibiotics, remains an alarming issue. OBJECTIVES: To analyze temporal trends in antibiotic consumption and its correlation with the development of antimicrobial resistance in first bacterial isolates of blood cultures from ten consecutive years. METHODS: observational, retrospective, single-center study carried out in a Brazilian tertiary university hospital. The correlation of temporal trends of antibiotic use (DDD/100 patient-day) with the rate of resistant isolates from selected bacteria first blood cultures were analyzed over ten years. RESULTS Cephalosporins were the most used class of antibiotics and presented the highest resistance profiles, with ceftriaxone being the most used antibiotic. However, there were different patterns of time trends relating the use of antibiotics and the development of bacterial resistance. There was an increase in resistance to A. baumannii (amikacin, ceftazidime, imipenem and piperacillin-tazobactam) and K. pneumoniae (cephalosporins, carbapenems, piperacillin-tazobactam, polymyxin, Tigecycline). K. pneumoniae showed a significant positive correlation between consumption and resistance for imipenem, meropenem, piperacillintazobactam, polymyxin, tigecycline and A. baumannii with ampicillin-sulbactam. CONCLUSION: There were significant correlations between antibiotic use and development of resistance, but with different evolution patterns related to the different bacteria and antibiotics analyzed which may imply different genetic mechanisms involved for Acinetobacter baumannii and Klebsiella pneumoniae.