Navegando por Palavras-chave "Deficiência De Ferro"
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- ItemSomente MetadadadosAssociação entre o uso prolongado de omeprazol e a deficiência de vitamina B12, ferro e magnésio em indivíduos muito idosos independentes(Universidade Federal de São Paulo (UNIFESP), 2021) Didone, Thiago Vinicius Nadaleto [UNIFESP]; Shinohara, Elvira Maria Guerra [UNIFESP]; Universidade Federal de São PauloThe aim of this study was to investigate the association between long-term use of omeprazole and magnesium, vitamin B12 and iron deficiency. Therefore, people aged ≥80 years and functionally independent, participating in the Longevous Project (Discipline of Geriatrics and Gerontology, EPM/UNIFESP), were followed retrospectively for 2 years. Users of stomach acid suppressants, other than omeprazole, and dietary supplements containing the micronutrients of interest, and those with hematological diseases and health conditions that may interfere with the absorption of these micronutrients, were excluded. We obtained primary data, from serum aliquots, and secondary data, from medical record, at baseline (T0) and after 1 (T1) and 2 (T2) years of follow-up. Information on the use of medications was self-reported. The individuals were divided between users (OMP group) and non-users (CTR group) of omeprazole. Levels of the micronutrients of interest (magnesium, vitamin B12, ferritin, transferrin saturation and iron) were quantified in serum samples. Differences in their levels over time were investigated using Friedman's analysis of variance. The accumulated incidence of magnesium deficiency (<0.7mM), vitamin B12 (150ρM) and iron (ferritin <30μg/L) were calculated at T1 and T2. Logistic regression models calculated the odds ratio for the development of deficiency between the OMP and CTR groups. In relation to T0, vitamin B12 levels decreased at T2 both in the OMP (P=.001) and CTR (P=.003) groups; transferrin saturation decreased at T2 only in the OMP group (P=.025). The levels of the other micronutrients did not change over time. The incidence of magnesium, vitamin B12 and iron deficiency did not differ between the OMP and CTR groups at T1 or T2. There was no significant odds ratio between the use of omeprazole and magnesium, vitamin B12 or iron deficiency in T1 or T2. These effect estimates were tested for moderation effects for the following covariates: gender, age, Charlson's comorbidity index, presence of diseases (type 2 diabetes mellitus, neoplasms, thyroid diseases or diseases for which omeprazole use is indicated), kidney function, ultra-sensitive c-reactive protein and the use of medications (diuretics, metformin, non-steroidal anti-inflammatory drugs, antithrombotics, calcium and vitamin D); no moderation effect was found. This work contributes to the understanding of the relationship between the use of proton pump inhibitors and the deficiency of magnesium, vitamin B12 and iron, whose causality remains controversial.
- ItemAcesso aberto (Open Access)Estratégias de fortificação de ferro na prevenção da anemia ferropriva em ambiente escolar: um estudo de revisão(Universidade Federal de São Paulo (UNIFESP), 2018-09-06) Juliao, Laiz [UNIFESP]; Bandoni, Daniel Henrique [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Iron deficiency anemia is considered the most important nutritional disease in the world, especially in childhood. Within this context, the promotion of healthy habits, combined with the set of intervention strategies and programs in the school environment can combat and prevent anemia. The objective of this study was to systematically review the literature on strategies for the prevention of iron deficiency anemia in schoolchildren and the impact of these strategies on population health. The databases National Library of Medicine and the National Institutes of Health (PubMed), Scientific Electronic Library Online (SciELO), Google Scholar and manual search in the references selected for the review were searched. We included original studies describing results regarding prevention or treatment in preschoolers and schoolchildren who received some type of supplementation or interventions aimed at the prevention or treatment of iron deficiency anemia in school settings. Eight studies were selected that met the inclusion criteria. Interventions had a heterogeneous duration (2 to 24 months), and all of them used food fortification or iron water to improve hemoglobin levels and reduce the prevalence of anemia in children of pre-school age. We observed that, regardless of the dose, the time of administration and the strategy used, the results were positive and showed that fortification of foods in a school environment can be a potential facilitator for the prevention of anemia and improvement of children's hemoglobin levels in the first childhood, which are considered the most susceptible groups.
- ItemSomente MetadadadosPerfil de expressão de proteínas no estriado e hipocampo após a restrição de ferro na dieta(Universidade Federal de São Paulo (UNIFESP), 2020-08-27) Pino, Jessica Monteiro Volejnik [UNIFESP]; Lee, Kil Sun [UNIFESP]; Universidade Federal de São PauloIron deficiency is a common nutritional disorder and is considered a major public health problem that affects all age groups. Its main consequence is the development of anemia, but studies have shown that iron deficiencies also impair central nervous system functions. We found in our previous study, following a restricted iron diet, changes in dopamine metabolism and oxidative stress levels in different brain regions. Therefore, to better understand how iron restriction affects brain functions, we investigated the protein profile of two distinct striatum and hippocampus brain regions after a 30 day restricted iron diet. In the striatum, a reduction of several glycolytic pathway enzymes was observed with the concomitant increase in lipid catabolism-related enzymes in the group on an iron restricted (IR) diet. In contrast to the hippocampus, proteins related to oxidative phosphorylation and neurodegenerative diseases were altered in the IR group. These changes occurred without reducing local iron levels, despite the dramatic reduction in hepatic iron and ferritin. On the other hand, the IR group showed an increase in blood glucose compared to the control group (CTL). These data suggest that iron content in the brain is preserved under initial iron deficiency conditions, but there are changes in other systemic metabolites, such as glucose, which may trigger metabolic adaptations in the brain. Thus, altered energy metabolism may be one of the mechanisms by which iron deficiency affects central nervous system functions.