Navegando por Palavras-chave "Genetic Polymorphisms"

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    Estudo de associação entre polimorfismos dos genes ERCC1 e ABCB1 e nefro-hepatotoxicidade à quimioterapia com Paclitaxel/Carboplatina em pacientes com câncer ginecológico
    (Universidade Federal de São Paulo (UNIFESP), 2020-03-05) Costa Junior, Luiz Carlos Da [UNIFESP]; Santos, Paulo Caleb Junior De Lima [UNIFESP]; Vianna-Jorge, Rosane [UNIFESP]; http://lattes.cnpq.br/7806610722907256; http://lattes.cnpq.br/7270343730265469; http://lattes.cnpq.br/1669800539285831; Universidade Federal de São Paulo
    Background: Paclitaxel/carboplatin combination is the standard chemotherapeutic protocol for gynecological cancers, but severe toxicities such as nephro and hepatotoxicity may compromise treatment. There is great interindividual variability regarding the incidence and severity of toxicities, which may be accounted to single nucleotide polymorphisms (SNPs) affecting drug transport or cellular sensitivity. Objective: To evaluate the impact of selected SNPs in ERCC1 and ABCB1 genes on the incidence of nephro- and hepatotoxicity in patients with gynecological cancer treated with paclitaxel/carboplatin. Methods: A cohort of 507 gynecological cancer patients receiving paclitaxel/carboplatin from the Brazilian National Cancer Institute (INCA-Brazil). Clinical data were obtained during routine consults or at electronic medical records. Hepatic and renal toxicities were graded according to the Common Terminology Criteria for Adverse Events (CTCAE 5.0). Genotyping was performed using real-time PCR. Results: ABCB1 c.1236C>T was associated with moderate to severe (grades 2- 4) nephrotoxicity (OR: 2.40; 95% CI 1.39–4.15), whereas ERCC1 c.118C>T was associated with moderate to severe hepatotoxicity (OR 3.71; 95% CI 1.08– 12.77). Conclusions: ABCB1 c.1236C>T and ERCC1 c.118C>T can be potential biomarkers for the risk of nephro- and hepatotoxicity to carboplatin/paclitaxel chemotherapy of gynecological cancers.