Navegando por Palavras-chave "Infecção De Corrente Sanguínea"

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    Caracterização fenotípica e molecular de Staphylococcus aureus isolados de infecções de corrente sanguínea adquiridas em ambiente hospitalar em estudo multicêntrico - Projeto SCOPE Brasil
    (Universidade Federal de São Paulo (UNIFESP), 2020-10-29) Lorenzete, Katia Daliria [UNIFESP]; Pignatari, Antonio Carlos Campos [UNIFESP]; Universidade Federal de São Paulo
    Bloodstream infections (BSIs) rank as a major problem not only in Brazil but also in developed countries. Staphylococcus aureus ranks as the five most prevalent agents causing BSI in healthcare settings. In the present study we evaluated the epidemiological analysis and performed phenotypic and molecular tests of Staphylococcus aureus isolated from a National Surveillance Study in Brazil - BrSCOPE. We studied 191 episodes of BSI caused by Staphylococcus aureus and we performed phenotypic and molecular tests for the characterization of resistance mechanisms to oxacillin. We also carried out molecular chracterization of SCCmec and MLST of the isolates. Most of the patients were men with median age of 56 years old. Pediatric population accounted for 12.5% of the cases. Central venous catheter, urinary catheter, and mechanical ventilation were the most predisposing factors observed and malignancy and renal diseases were the underlying conditions most observed in this population. The crude mortality was 35.6%. For patients who needed ICU support this rate was 45.3% and 27.8% for those who did not. From the 191 isolates of Staphylococcus aureus, 83 (43.4%) were oxacillin resistant. The crude mortality for patients who had BSI caused by MRSA was 46.9% (39) while those with MSSA 28.0% (28)(p=0,002) We performed the molecular characterization of the SCCmec of 44 isolates oxacillin resistant. We observed the prevalence of the SCCmec type III (43%) followed by the SCCMEC type II (27%) and IV (18%). Only one isolate was nontypable according the protocol used and belonged to the ST 239.