Navegando por Palavras-chave "Low-level"

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    Os efeitos da terapia a laser de baixa intensidade na neuroplasticidade e recuperação funcional da lesão medular
    (Universidade Federal de São Paulo (UNIFESP), 2015-05-29) Silva, Suellen de Oliveira Veronez [UNIFESP]; De Oliveira, Flavia [UNIFESP]; http://lattes.cnpq.br/3387760393535776; http://lattes.cnpq.br/9642448821553030; Universidade Federal de São Paulo (UNIFESP)
    Spinal cord injury (SCI) is an irreversible injury of high economic and social cost. In addition, this type of injury has important functional impairment, as it causes decrease in sensory-motor functions and systemic changes. The low level laser therapy (LLLT) has demonstrated beneficial effects on the nervous system, as it is able to penetrate into the spinal cord level and improve axonal regeneration, moreover, shown to be beneficial in the recovery of specific motor functions. The objective of this study was to analyze the effects of LLLT after LME on the functionality, the inflammatory process and neuroplastic after spinal cord injury. This study was approved by the Ethics Committee of the Federal University of São Paulo (2014/743029). 64 female wistar rats were randomly divided into 8 groups: (n = 8): CG: Control group 7 days - spinal cord injury without LLLT application; L7-500: Experimental group with spinal cord injury and treated with LLLT 500 J/cm2; L7-750: Experimental group with spinal cord injury and treated with LLLT 750 J/cm2; L7-1000: Experimental group with spinal cord injury and treated with LLLT 1000 J/cm2; GC-15: Control group 15 days - spinal cord injury without LLLT application; L15-500: Experimental group with spinal cord injury and treated with LLLT 500 J/cm2 ; L15-750: Experimental group with spinal cord injury and treated with LLLT 750 J/cm 2 ; L15-1000: Experimental group with spinal cord injury and treated with LLLT 1000 J/cm 2 . The animals had a contusion lesion by equipment Impactor between the segment T9-T10 SCI and 15 minutes after the injury the treatment was initiated, which was repeated for 7 consecutive days. Irradiation was performed using low level laser (AlGaAs, continuous wave 808 nm, 100 mW, 500,750,1000 J / cm2, 0,028 cm2, 1.7 mW / cm2; irradiation time 2:22 3 : 32 and 4:42 respectively - PHOTON LASER II, DMC® São Carlos, Brazil). Irradiation occurred at a point located above the lesion, the animals were euthanized in 8 th and 15 th day after injury. 24 hours after the injury and on the 7th day was performed evaluation of motor function, assessment of tactile and thermal sensitivity. After the euthanasia the tissue was processed for, histology, morphometric and immunohistochemistry analysis. The results showed that LLLT with a dose of 1000 J / cm² was able to improve engine performance and improve tactile sensitivity at 7-1000 group and L14-1000 group (p <0.05). It was also seen a reduction in lesion volume and decrease in density apoptosis in groups L7-750, L7-1000, and L14-1000. The groups L7-750 and L14-1000 showed a decrease in CD-68 expression and caspase-3 (P <0.05). It was concluded that LLLT at higher doses was able to modulate the inflammatory process, decrease the process of tissue degeneration and promote functional recovery after SCI.
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    Phototherapy 660 nm for the prevention of radiodermatitis in breast cancer patients receiving radiation therapy: study protocol for a randomized controlled trial
    (Biomed Central Ltd, 2014-08-20) Costa, Marina Moreira; Silva, Sidney Benedito; Quinto, Ana Luiza Pereira; Pasquinelli, Priscilla Furtado Souza; Santos, Vanessa de Queiroz dos; Santos, Gabriela de Cassia; Veiga, Daniela Francescato [UNIFESP]; Hosp Canc Barretos; Univ Vale Sapuca; Oncominas; Universidade Federal de São Paulo (UNIFESP)
    Background: Breast neoplasms are the second most common type of cancer worldwide, and radiation therapy is a key component of their treatment. Acute skin reactions are one of the most common side effects of radiation therapy, and prevention of this adverse event has been investigated in several studies. However, a clinically applicable, preventative treatment remains unavailable. It has been demonstrated that application of a low-power laser can promote tissue repair. Therefore, the aim of this trial is to evaluate the effectiveness of an indium gallium aluminum phosphorus (InGaAIP) laser operated at 660 nm in preventing radiodermatitis in women undergoing adjuvant radiotherapy for breast cancer.Methods/Design: This is a two-arm, randomized controlled trial. A total of 52 patients undergoing radiotherapy for breast cancer (stages I to III) will be enrolled. Patients will be randomly assigned to an intervention group to receive laser therapy (n = 26) or a control group to receive a placebo (n = 26). the laser or placebo will be applied five days a week, immediately before each radiotherapy session. Skin reactions will then be graded weekly by a nurse, a radiotherapist, and an oncologist (all of whom will be blinded) using the Common Toxicity Criteria (CTC) developed by the National Cancer Institute and the Acute Radiation Morbidity Scoring Criteria developed by the Radiation Therapy Oncology Group. Patients will also answer a modified visual analogue scale for pain (a self-evaluation questionnaire). Primary and secondary outcomes will be the prevention of radiodermatitis and pain secondary to radiodermatitis, respectively.Discussion: the ideal tool for preventing radiodermatitis is an agent that mediates DNA repair or promotes cell proliferation. Application of a low-power laser has been shown to promote tissue repair by reducing inflammation and inducing collagen synthesis. Moreover, this treatment approach has not been associated with adverse events and is cost-effective. Thus, the results of this ongoing trial may establish whether use of a low-power laser represents an ideal treatment option for the prevention of radiodermatitis.
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    Terapia a laser de baixa intensidade na neuroplasticidade e recuperação funcional da lesão medular
    (Universidade Federal de São Paulo (UNIFESP), 2016) Campo, Paula Fernanda Gallani Martin Del [UNIFESP]; Aguiar, Odair [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: The spinal cord injury (SCI) consists of any damages to the structures in the medullary canal. This injury can be traumatic or non-traumatic, the latter being the most common. The central nervous system (CNS) has a low ability to get repaired, requiring the use of therapeutic approaches in order to favor neuroplasticity. In this context, low-level laser therapy (LLLT) has been proposed as a promising treatment for repairing central and peripheral nervous system injuries. Aim: to investigate the effects of LLLT, after traumatic injuries, on the regeneration and neuroplasticity of the spinal cord, as well as on the sensorial and motor functional recovery. Materials and methods: female wistar rats (n= 33), aging 10 weeks, were submitted to spinal cord injury contusion model (CEUA N: 9329290514). The animals were divided into two groups: control (C; n= 19) and laser (L; n= 14), and they were euthanized after 4 and 8 weeks. The L group was treated, for 15 consecutive days, with continuous emission of GaAlAs laser which was adjusted with the following parameters: λ = 808 nm, power of 100 mW, spot area = 0.028 cm²; t = 4'42 ''; dosage of 1000 J / cm²; E = 28 J; irradiance = 3.57 mW / cm². At days 1, 14, 28 and 56 after the surgery, the motor function (using BBB score and computed kinematics), the thermal sensitivity (using ice) and the tactile sensitivity (using Von Frey® monofilaments) were evaluated. Additionally, histological and immunohistochemical analysis were performed to investigate the lesion volume and the expression of GFAP respectively. Results: The main findings of this study demonstrate, based on the BBB score, that LLLT was able to improve the motor performance in the group L compared to group C after 56 days. Furthermore, LLLT was capable to decrease the immunoexpression of of GFAP marker and the lesion volume in the injury site after 56 days. Conclusion: Based on the results, it is suggested that the effect of LLLT in the lesion (i) assisted in the motor recovery; (ii) reduced the lesion volume and (iii) decreased the GFAP immunostaining. This study indicates that the LLLT is a promising therapeutic approach for the SCI treatment, justifying the need of further investigations utilizing other experimental models and other specific markers.