Navegando por Palavras-chave "Myelodysplastic Syndrome"

Agora exibindo 1 - 1 de 1
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients
    (Elsevier B.V., 2013-05-01) Lopes, Matheus Rodrigues; Traina, Fabíola; Campos, Paula de Melo; Pereira, João Kleber Novais; Machado-Neto, João Agostinho; Machado, Helymar da Costa; Gilli, Simone Cristina Olenscki; Saad, Sara Teresinha Olalla; Favaro, Patricia [UNIFESP]; Universidade Estadual de Campinas (UNICAMP); Universidade Federal de São Paulo (UNIFESP)
    The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGF beta 1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. (C) 2013 Elsevier B.V. All rights reserved.