IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients

Lopes, Matheus Rodrigues; Traina, Fabíola; Campos, Paula de Melo; Pereira, João Kleber Novais; Machado-Neto, João Agostinho; Machado, Helymar da Costa; Gilli, Simone Cristina Olenscki; Saad, Sara Teresinha Olalla; Favaro, Patricia [UNIFESP]

IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients

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WOS000317264500012.pdf(375.9 KB)

Data

2013-05-01

Autores

Lopes, Matheus Rodrigues

Traina, Fabíola

Campos, Paula de Melo

Pereira, João Kleber Novais

Machado-Neto, João Agostinho

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Tipo

Artigo

Resumo

The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGF beta 1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. (C) 2013 Elsevier B.V. All rights reserved.

Citação

Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 37, n. 5, p. 541-546, 2013.