IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients

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dc.contributor.authorLopes, Matheus Rodrigues
dc.contributor.authorTraina, Fabíola
dc.contributor.authorCampos, Paula de Melo
dc.contributor.authorPereira, João Kleber Novais
dc.contributor.authorMachado-Neto, João Agostinho
dc.contributor.authorMachado, Helymar da Costa
dc.contributor.authorGilli, Simone Cristina Olenscki
dc.contributor.authorSaad, Sara Teresinha Olalla
dc.contributor.authorFavaro, Patricia [UNIFESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:36Z
dc.date.available2016-01-24T14:31:36Z
dc.date.issued2013-05-01
dc.description.abstractThe role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGF beta 1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, Haematol & Hemotherapy Ctr, Hemoctr Unicamp, Inst Nacl Ciencia & Tecnol Sangue, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Sch Med Sci, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent541-546
dc.identifierhttp://dx.doi.org/10.1016/j.leukres.2013.01.019
dc.identifier.citationLeukemia Research. Oxford: Pergamon-Elsevier B.V., v. 37, n. 5, p. 541-546, 2013.
dc.identifier.doi10.1016/j.leukres.2013.01.019
dc.identifier.fileWOS000317264500012.pdf
dc.identifier.issn0145-2126
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36229
dc.identifier.wosWOS:000317264500012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLeukemia Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMyelodysplastic Syndromeen
dc.subjectIL10en
dc.subjectCD8(+) cellsen
dc.subjectImmune Systemen
dc.titleIL10 inversely correlates with the percentage of CD8(+) cells in MDS patientsen
dc.typeinfo:eu-repo/semantics/article
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