Navegando por Palavras-chave "Radiological Changes"

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    Doença Fúngica Invasiva Por Fungo Filamentoso: Aspectos Radiológicos Encontrados Em Pacientes Pediátricos Com Câncer Atendidos No Instituto De Oncologia Pediátrica- Graacc-Unifesp
    (Universidade Federal de São Paulo (UNIFESP), 2017-03-29) Milare, Luiza De Souza Santos [UNIFESP]; Lederman, Henrique Manoel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Currently, with the evolution in the treatment of cancer, introduction of new antineoplastic drugs leading to prolonged granulocytopenia and the possibility of transplantation of hematopoietic stem cells (HSCT) 1, infectious complications have become the major causes of morbidity and mortality in these patients. Among them are diseases invasive fungi (DFI) are highlighted. Candida spp. remains the main agent However, an etiological finding in the DFI, however, has been observed an increase in the infections with filamentous fungi especially Aspergillus spp., and Fusarium spp. The incidence of invasive aspergillosis (AI) has increased by 357% since 19802. adult population are contributing to the knowledge of this disease, however, few data are observed in the pediatric population. It is important to emphasize that the disease especially those with haematological malignancies due to the high degree of immunosuppression and prolonged neutropenia, and that in spite of the evolution of the methods and the use of prophylactic antifungals, mortality 52%, with HSCT being an independent risk factor3. The principal procurement mechanism is the inhalation of spores being the breasts of the face and the lung the most affected organs. Research indicate the Aspergillus flavus as the most common in the pediatric population3. Fusarium spp. is another emerging cause of DFI mainly in Brazil4, with a high rate of mortality in this population, reaching 70% 5. The mode of acquisition is variable and the breakdown of the skin barrier such as onychomycosis6 and the inhalation of spores frequently. Central venous catheter infection is less common. About 50 However, F. oxysporum and F.solani account for 70% of humans5. Fusarium spp. has a high degree of systemic spread and can cause fungemia and characteristic skin lesions in immunosuppressed patients. Therefore, due to the high mortality rate and the therapeutic limitation for these agents, it is diagnosis is performed early. Imaging exams are a an important tool for the detection of DFI, but currently published works are aimed at the adult population. The pediatric population has its own characteristics which makes the extrapolation of these data at least inappropriate.