Navegando por Palavras-chave "Technetium"

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    Exercise may cause myocardial ischemia at the anaerobic threshold in cardiac rehabilitation programs
    (Associação Brasileira de Divulgação Científica, 2009-03-01) Fuchs, Angela Rúbia Cavalcanti Neves [UNIFESP]; Meneghelo, Romeu Sergio; Stefanini, Edson [UNIFESP]; De Paola, Angelo Amato Vincenzo [UNIFESP]; Smanio, Paola Emanuela Poggio; Mastrocolla, Luiz Eduardo; Ferraz, Almir Sergio; Buglia, Susimeire; Piegas, Leopoldo Soares; Carvalho, Antonio Carlos [UNIFESP]; Instituto Dante Pazzanese de Cardiologia Serviço de Reabilitação Cardiovascular; Instituto Dante Pazzanese de Cardiologia Seção Médica de Medicina Nuclear; Instituto Dante Pazzanese de Cardiologia Departamento de Saúde; Universidade Federal de São Paulo (UNIFESP)
    Myocardial ischemia may occur during an exercise session in cardiac rehabilitation programs. However, it has not been established whether it is elicited when exercise prescription is based on heart rate corresponding to the anaerobic threshold as measured by cardiopulmonary exercise testing. Our objective was to determine the incidence of myocardial ischemia in cardiac rehabilitation programs according to myocardial perfusion SPECT in exercise programs based on the anaerobic threshold. Thirty-nine patients (35 men and 4 women) diagnosed with coronary artery disease by coronary angiography and stress technetium-99m-sestamibi gated SPECT associated with a baseline cardiopulmonary exercise test were assessed. Ages ranged from 45 to 75 years. A second cardiopulmonary exercise test determined training intensity at the anaerobic threshold. Repeat gated-SPECT was obtained after a third cardiopulmonary exercise test at the prescribed workload and heart rate. Myocardial perfusion images were analyzed using a score system of 6.4 at rest, 13.9 at peak stress, and 10.7 during the prescribed exercise (P < 0.05). The presence of myocardial ischemia during exercise was defined as a difference ≥2 between the summed stress score and summed rest score. Accordingly, 25 (64%) patients were classified as ischemic and 14 (36%) as nonischemic. MIBI-SPECT showed myocardial ischemia during exercise within the anaerobic threshold. The 64% prevalence of ischemia observed in the study should not be looked on as representative of the whole population of patients undergoing exercise programs. Changes in patient care and exercise programs were implemented as a result of our finding of ischemia during the prescribed exercise.
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    Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core
    (Elsevier B.V., 2011-04-01) Fernandez Nunez, Eutimio Gustavo; Faintuch, Bluma Linkowski; Teodoro, Rodrigo; Wiecek, Danielle Pereira; Silva, Natanael Gomes da; Papadopoulos, Minas; Pelecanou, Maria; Pirmettis, Loannis; Oliveira Filho, Renato Santos de [UNIFESP]; Duatti, Adriano; Pasqualini, Roberto; Inst Energet & Nucl Res; Natl Ctr Sci Res Demokritos; Universidade Federal de São Paulo (UNIFESP); Univ Ferrara; CIS Bio Int
    The objective of this study was the development of a statistical approach for radiolabeling optimization of cysteine-dextran conjugates with Tc-99m tricarbonyl core. This strategy has been applied to the labeling of 2-propylene-S-cysteine-dextran in the attempt to prepare a new class of tracers for sentinel lymph node detection, and can be extended to other radiopharmaceuticals for different targets. the statistical routine was based on three-level factorial design. Best labeling conditions were achieved. the specific activity reached was 5 MBq/mu g. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.