Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core
Data
2011-04-01
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Artigo
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Resumo
The objective of this study was the development of a statistical approach for radiolabeling optimization of cysteine-dextran conjugates with Tc-99m tricarbonyl core. This strategy has been applied to the labeling of 2-propylene-S-cysteine-dextran in the attempt to prepare a new class of tracers for sentinel lymph node detection, and can be extended to other radiopharmaceuticals for different targets. the statistical routine was based on three-level factorial design. Best labeling conditions were achieved. the specific activity reached was 5 MBq/mu g. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
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Applied Radiation and Isotopes. Oxford: Pergamon-Elsevier B.V., v. 69, n. 4, p. 663-669, 2011.