Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core

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dc.contributor.authorFernandez Nunez, Eutimio Gustavo
dc.contributor.authorFaintuch, Bluma Linkowski
dc.contributor.authorTeodoro, Rodrigo
dc.contributor.authorWiecek, Danielle Pereira
dc.contributor.authorSilva, Natanael Gomes da
dc.contributor.authorPapadopoulos, Minas
dc.contributor.authorPelecanou, Maria
dc.contributor.authorPirmettis, Loannis
dc.contributor.authorOliveira Filho, Renato Santos de [UNIFESP]
dc.contributor.authorDuatti, Adriano
dc.contributor.authorPasqualini, Roberto
dc.contributor.institutionInst Energet & Nucl Res
dc.contributor.institutionNatl Ctr Sci Res Demokritos
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Ferrara
dc.contributor.institutionCIS Bio Int
dc.date.accessioned2016-01-24T14:06:21Z
dc.date.available2016-01-24T14:06:21Z
dc.date.issued2011-04-01
dc.description.abstractThe objective of this study was the development of a statistical approach for radiolabeling optimization of cysteine-dextran conjugates with Tc-99m tricarbonyl core. This strategy has been applied to the labeling of 2-propylene-S-cysteine-dextran in the attempt to prepare a new class of tracers for sentinel lymph node detection, and can be extended to other radiopharmaceuticals for different targets. the statistical routine was based on three-level factorial design. Best labeling conditions were achieved. the specific activity reached was 5 MBq/mu g. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationInst Energet & Nucl Res, Radiopharm Ctr, BR-05508000 São Paulo, Brazil
dc.description.affiliationNatl Ctr Sci Res Demokritos, Inst Radioisotopes, Athens, Greece
dc.description.affiliationNatl Ctr Sci Res Demokritos, Inst Biol, Athens, Greece
dc.description.affiliationUniversidade Federal de São Paulo, Fac Med, São Paulo, SP, Brazil
dc.description.affiliationUniv Ferrara, Dept Radiol Sci, I-44100 Ferrara, Italy
dc.description.affiliationCIS Bio Int, Gif Sur Yvette, France
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Fac Med, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Commission for Nuclear Energy (CNEN, São Paulo, Brazil)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInternational Atomic Energy Agency (IAEA, Vienna, Austria)
dc.format.extent663-669
dc.identifierhttp://dx.doi.org/10.1016/j.apradiso.2011.01.006
dc.identifier.citationApplied Radiation and Isotopes. Oxford: Pergamon-Elsevier B.V., v. 69, n. 4, p. 663-669, 2011.
dc.identifier.doi10.1016/j.apradiso.2011.01.006
dc.identifier.issn0969-8043
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33591
dc.identifier.wosWOS:000287893700003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofApplied Radiation and Isotopes
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subject[(99m)Tc(OH(2))(3)(CO)(3)](+) precursoren
dc.subjectTechnetiumen
dc.subjectRadiolabelingen
dc.subjectExperimental designen
dc.subjectDextranen
dc.subjectStatistical analysisen
dc.titleParameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl coreen
dc.typeinfo:eu-repo/semantics/article
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