Navegando por Palavras-chave "Tioridazina"

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    Caracterização farmacológica da Crotamina sintética como antitumoral em modelos de melanoma in vivo. Otimização da atividade neoplásica com uso de adjuvantes
    (Universidade Federal de São Paulo (UNIFESP), 2020-05-28) Porta, Lucas De Carvalho [UNIFESP]; Hayashi, Mirian Akemi Furuie [UNIFESP]; Universidade Federal de São Paulo
    Toxins are of great scientific interest, mainly due to their possible use for therapeutic purposes as drugs, or as a structural model for its development. Crotamine, which is one of the most abundant toxins present in the rattlesnake venom, can penetrate cells, with special specificity and cytotoxic activity against active proliferating cells. Daily treatment of animal models of melanoma, with crotamine administered through intraperitoneal or oral routes, showed a significant remission of tumor growth such as an increase in survival of the treated animals. In order to continue and improve the anti-tumor treatment with crotamine, the present work consisted to show the use of crotamine obtained by chemical synthesis, associated with thioridazine or with silica nanoparticles in the therapy of animal models of melanoma, such as the evaluation of treatment-related toxicity through the administration of these associated compounds in isolated skeletal muscle or with high doses injections in vivo. The remission of tumor growth in vivo was evaluated comparing these associations/formulations with the effect of native crotamine alone, suggesting that, although significant toxicity has been observed in the treatment with crotamine associated with thioridazine, which is not due to local effect, it is feasible to decrease the amount of crotamine needed for anti-tumor treatment.