Navegando por Palavras-chave "Vacina BCG"
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- ItemAcesso aberto (Open Access)Asma e doenças alérgicas em escolares de população ribeirinha da região leste da Amazônia(Universidade Federal de São Paulo (UNIFESP), 2011-05-25) Freitas, Marly Sarmanho de Souza [UNIFESP]; Solé, Dirceu [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Background: epidemiological studies have focused on possible association between helminth infection and the development of asthma and/or allergies. Objectives: to evaluate the association between helminth infection and asthma and its relation to serum levels of total and specific IgE for A. lumbricoides and aeroallergens, besides evaluating possible relation between BCG scar and allergic sensitization. Methods: cross sectional study in 400 schoolchildren from two Amazon Islands. A standardized written questionnaire (asthma module) from International Study of Asthma, Allergies in Childhood protocol was administered and asthmatic children were those with current wheezing. The following procedures were done: skin prick test (positive test with papule mean diameter > 3mm); blood samples for assessment of serum levels of total and specific IgE for A. lumbricoides and aeroallergens (positive those with levels > 0.36 kU/L); feces samples for helminths examination (positive = infected with at least one helminth); mean diameter of BCG vaccine scar measurement. Analyses were assessed for both islands together and non-parametric tests were applied obtaining 5% of significance level. Results: there was no significant difference between infected and non-infected children with helminths related to asthma expression, save for having physician-diagnosed asthma that was more frequent in helminths infected children. Serum levels of total and specific IgE for A. lumbricoides were higher in infected children. Significant correlations between serum levels of total and specific IgE for aeroallergens to Periplaneta americana and Ascaris lumbricoides among those infected and among those non-infected was for B. germanica e B. tropicalis. Significant correlation between papule mean diameter and serum level of specific IgE for D. pteronyssinus e B. tropicalis among those not infected. Mean diameter of BCG vaccine wasn´t different among children with asthma and those without, as well as there was no correlation between serum levels of total and specific IgE. Conclusions: parasite infections are not associated with either asthma expression or to allergic sensitization, but positive association was verified between physician-diagnosed asthma and helminth infection. More studies are necessary to clarify helminth infection role on asthma and allergic diseases.
- ItemSomente MetadadadosAvaliacao da reacao tecidual dos hansenianos polares ao BCG intradermico(Universidade Federal de São Paulo (UNIFESP), 1986) Rotta, Osmar [UNIFESP]
- ItemSomente MetadadadosAvaliação da resposta específica imune-celular em crianças, antes e após vacinação com BCG intradérmico: correlação entre teste cutâneo e índice de transformação linfoblástica, utilizando-se PPD como estímulo antigênico(Universidade Federal de São Paulo (UNIFESP), 1982) Brito, Paulo Juaci de Almeida [UNIFESP]
- ItemSomente MetadadadosCaracterizacao imunologica e funcional de proteinas do complexo 85 de Mycobacterium tuberculosis(Universidade Federal de São Paulo (UNIFESP), 1993) Leao, Sylvia Luisa Pincherle Cardoso [UNIFESP]
- ItemSomente MetadadadosComparação dos testes cutâneos PPD e BCG teste no diagnóstico de tuberculose na infância(Universidade Federal de São Paulo (UNIFESP), 1991) Braga, Edson Taipina [UNIFESP]; Silvestrini, Wagner Sérgio [UNIFESP]
- ItemSomente MetadadadosComportamento do teste tuberculinico e evolucao da lesao vacinal pos-BCG em criancas expostas e/ou infectadas pelo virus da imunodefiCiência humana(Universidade Federal de São Paulo (UNIFESP), 2003) Nunes, Alex Moura de Barros [UNIFESP]Objetivos: estudar a evolucao da lesao vacinal pos-BCG (papula, enduracao, eritema, supuracao e cicatriz) em criancas expostas ao HIV (infectadas ou nao); identificar eventos adversos ao BCG; 4 avaliar o comportamento do teste tuberculinico e a contribuicao deste teste ao diagnostico da tuberculose, nesta populacao. Metodos: o trabalho foi realizado no ambulatorio de AIDS pediatrico da UNIFESP-EPM, entre marco de 2000 e fevereiro de 2002, em São Paulo-SP. Estudo prospectivo de 105 lactentes expostos ao HIV por via perinatal (grupo A) e estudo transversal de 109 criancas e adolescentes com infeccao pelo HIV previamente confirmada (grupo B). Todos receberam o BCG intradermico apos o nascimento e foram acompanhados atraves de exame fisico, laboratoriais e analise de prontuario. O teste tuberculinico foi realizado seis a 12 meses apos o BCG, no grupo A. Resultados: Grupo A: papula, enduracao, eritema, supuracao e cicatriz aparecem com tres a quatro semanas (papula); quatro a cinco semanas (enduracao e eritema); sete semanas (supuracao) e 10 a 12 semanas (cicatriz). Nao foram observados eventos adversos a vacina BCG, exceto cicatrizacao com tempo superior a seis meses em um lactente infectado. Houve apenas 10 por cento de testes tuberculinicos com enduracoes iguais ou maiores a 10 mm e 62,5 por cento de testes iguais a zero. Grupo B: 94 por cento de anergia ao teste tuberculinico, sem correlacao com os fatores estudados. Nao houve associacao estatisticamente significante entre a enduracao do teste tuberculinico em ambos os grupos (A e B) e todas as variaveis analisadas: idade a epoca da vacinacao BCG, presenca ou ausencia de cicatriz pos BCG, tamanho da cicatriz, tempo decorrido entre o BCG e o teste tuberculinico e, ainda, no grupo A: idade gestacional, peso ao nascimento, tuberculose materna durante a gestacao. No grupo B nao houve associacao estatisticamente significante com a dosagem de RNA viral plasmatico, contagem de linfocitos T CD4+, tratamento anti-retroviral ou tuberculose passada. Foi estatisticamente significante a correlacao entre testes tuberculinicos com enduracoes diferentes de zero e diagnostico de tuberculose atual. Conclusoes - Grupo A: 60 por cento teve os resultados de teste tuberculinico iguais a zero, concluindo-se que a vacinacao previa com o BCG nao invalida a contribuicao deste teste ao diagnostico de infeccao tuberculosa, nesta populacao. Grupo B: o teste tuberculinico mostrou-se um importante instrumento para o diagnostico da infeccao tuberculosa
- ItemSomente MetadadadosEvento adverso locorregional pós-vacina BCG como sinalizador de defeito genético-molecular associado a um erro inato da imunidade(Universidade Federal de São Paulo (UNIFESP), 2021) Monteiro, Sandra Aparecida Moreira Gomes [UNIFESP]; Pinto, Maria Isabel De Moraes [UNIFESP]; Universidade Federal de São PauloObjectives: To describe the frequency of genetic variants associated with monogenic diseases with inborn errors of immunity in children who have had localized adverse events after BCG vaccination. Patients and Methods: Forty-four children (probands) with a history of localized adverse event to the BCG vaccine (BCGitis) who had an indication of specific drug treatment (isoniazid) were selected. For cases with a history of BCGitis in family members, when available, the other affected family members were included. Human immunodeficiency virus (HIV) infection was considered an exclusion criterion. All patients were evaluated with immunological tests, which included immunophenotyping of T, B and NK cells by flow cytometry, evaluation of phagocytic function (dihydro-rodamin test - DHR) and production of IL-12 and IFNg after in vitro stimulation with BCG and IL-12 or IFNg. When necessary, complement tests were performed and humoral immunity was assessed using immunoglobulins. Whole Exome Sequencing (WES) by New Generation Sequencing (NGS) was performed from peripheral blood samples. The exome sequences were filtered for variants in the 344 genes associated with 354 Inborn Errors of Immunity (IEI-Genes) described by the Primary Immunodeficiency Disease Committee of the International Union of Immunological Societies - IUIS. The candidate variants identified after NGS analysis that were selected were then validated by Sanger sequencing. Samples of the parents and/or siblings of the proband, when available, were submitted to Sanger sequencing to study family segregation. Results: Among the 44 probands, 36 were sporadic cases and eight had other cases of BCGitis in their family. Among the sporadic cases, 25/36 (69.4%) presented, besides BCGitis, immunoallergic conditions or other infectious conditions that required hospitalization. Among the sporadic cases, 15/36 (41.7%) presented variants in IEI-genes classified as pathogenic or likely pathogenic. Among familal cases, 6/8 (75%) presented, in addition to BCGitis, immunoalergic conditions or other infectious conditions that required hospitalization and of these, 4/8 (50%) presented variants in IEI-genes classified as probably pathogenic who met inclusion criteria in this analysis. Considering all probands in the initial cohort, 19/44 (43.2%) presented variants classified as pathogenic or likely pathogenic in IEI-genes. Conclusions: Variants in genes related to inborn erros of immunity and classified as pathogenic or likely pathogenic were found in the exoma analysis of 43.2% of the probands who presented a localized adverse event following BCG vaccination. All these variants found may be related to BCGitis, suggesting that these localized adverse events following BCG immunization may be indicative of a molecular defect related to an inborn error of immunity.
- ItemAcesso aberto (Open Access)O processo de imunoterapia intravesical com a vacina BCG - relato de experiência de ciclo PDCA(Universidade Federal de São Paulo, 2022) Ferreira, Giovanna Poletini [UNIFESP]; Draganov, Patrícia Bover [UNIFESP]; http://lattes.cnpq.br/7263104433879588; http://lattes.cnpq.br/0119340462015158Objetivo: Descrever um ciclo PDCA aplicado ao processo de imunoterapia intravesical com BCG no Ambulatório de Urologia durante o estágio curricular supervisionado de administração da graduação em Enfermagem de uma escola de enfermagem de uma universidade federal em São Paulo. Método: Estudo descritivo de intervenção sobre um ciclo PDCA que teve como produto a implementação de um novo processo, direcionados para usuários em imunoterapia com Onco-BCG intravesical. Resultados: realizou-se o diagnóstico situacional, índice Risk Priority Number (RPN) para priorização dos achados e o plano de ação para melhoria do processo em questão. As ações planejadas foram instituídas por meio da ferramenta PDCA de forma compartilhada com a equipe de trabalho. A consulta de Enfermagem direcionada para estes casos foi desenhada, testada e adicionada como parte do novo fluxo. Considerações finais: O novo processo repercutiu positivamente na qualidade da assistência prestada, na segurança do paciente e no trabalho em equipe.