Navegando por Palavras-chave "infectious disease"

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    Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients
    (Wiley-Blackwell, 2015-06-01) Ono, E. [UNIFESP]; Santos, A. M. dos [UNIFESP]; Viana, P. O. [UNIFESP]; Dinelli, M. I. S. [UNIFESP]; Sass, N. [UNIFESP]; De Oliveira, L. [UNIFESP]; Goulart, A. L. [UNIFESP]; Moraes-Pinto, M. I. de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Children born to female kidney recipients are exposed to immunosuppressive drugs during gestation. Little is known about their immune system at birth or in the long term. Twenty-eight children born to female kidney recipients and 40 full-term children born to healthy mothers were evaluated. T, B, NK, NKT, T cells were assessed by flow cytometry and functional evaluation of T and dendritic cells after in vitro activation was performed at birth and at 8 months of age. At birth, infants born to female kidney recipients showed lower numbers of CD4+ T, NKT and intense reduction of B cells (median cells/mm(3), transplant: 153.7 X control: 512.4; p<0.001). There was also a reduced percentage of activated CD8+ T and of CD4+ regulatory T cells. Activated memory and exhausted memory B cells showed higher percentages among children exposed to immunosuppressors when compared to control group. At 8 months, most immune alterations were no longer observed, but four children still had low numbers of some lymphocyte subsets at this age. Children born to female kidney recipients had 4.351 (95% CI: 1.026-15.225; p=0.046) higher risk of hospital admission in the first months of lifesome, with severe clinical manifestationsthan those born to healthy women.
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    Malaria vaccine: roadblocks and possible solutions
    (Associação Brasileira de Divulgação Científica, 1998-03-01) Soares, Irene da Silva [UNIFESP]; Rodrigues, Mauricio Martins [UNIFESP]; Universidade Federal do Pará; Universidade Federal de São Paulo (UNIFESP)
    Malaria remains the most prevalent and devastating parasitic disease worldwide. Vaccination is considered to be an approach that will complement other strategies for prevention and control of the disease in the future. In the last 10 years, intense studies aimed at the development of a malaria vaccine have provided important knowledge of the nature of the host immunological mechanisms of protection and their respective target antigens. It became well established that protective immune responses can be generated against the distinct stages of Plasmodium. However, in general, protective immune responses are directed at stage-specific antigens. The elucidation of the primary structure of these antigens made possible the generation of synthetic and recombinant proteins that are being extensively used in experimental immunizations against the infection. Today, several epitopes of limited polymorphism have been described and protective immunity can be generated by immunization with them. These epitopes are being tested as primary candidates for a subunit vaccine against malaria. Here we critically review the major roadblocks for the development of a malaria vaccine and provide some insight on how these problems are being solved
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    Risk Factors Associated With Early Invasive Pulmonary Aspergillosis in Kidney Transplant Recipients: Results From a Multinational Matched Case-Control Study
    (Wiley-Blackwell, 2016) Lopez-Medrano, F.; Silva, J. T.; Fernandez-Ruiz, M.; Carver, P. L.; van Delden, C.; Merino, E.; Perez-Saez, M. J.; Montero, M.; Coussement, J.; de Abreu Mazzolin, M. [UNIFESP]; Cervera, C.; Santos, L.; Sabe, N.; Scemla, A.; Cordero, E.; Cruzado-Vega, L.; Martin-Moreno, P. L.; Len, O.; Rudas, E.; Ponce de Leon, A.; Arriola, M.; Lauzurica, R.; David, M.; Gonzalez-Rico, C.; Henriquez-Palop, F.; Fortun, J.; Nucci, M.; Manuel, O.; Pano-Pardo, J. R.; Montejo, M.; Munoz, P.; Sanchez-Sobrino, B.; Mazuecos, A.; Pascual, J.; Horcajada, J. P.; Lecompte, T.; Lumbreras, C.; Moreno, A.; Carratala, J.; Blanes, M.; Hernandez, D.; Hernandez-Mendez, E. A.; Farinas, M. C.; Perello-Carrascosa, M.; Morales, J. M.; Andres, A.; Aguado, J. M.
    Risk factors for invasive pulmonary aspergillosis (IPA) after kidney transplantation have been poorly explored. We performed a multinational case-control study that included 51 kidney transplant (KT) recipients diagnosed with early (first 180 posttransplant days) IPA at 19 institutions between 2000 and 2013. Control recipients were matched (1:1 ratio) by center and date of transplantation. Overall mortality among cases was 60.8%, and 25.0% of living recipients experienced graft loss. Pretransplant diagnosis of chronic pulmonary obstructive disease (COPD