Navegando por Palavras-chave "neuropscyhology"

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    Correlatos neuropsicológicos da remissão sintomatológica na esquizofrenia: um estudo transversal com pacientes crônicos
    (Universidade Federal de São Paulo (UNIFESP), 2016-03-28) Souza, Thais Rabanea de [UNIFESP]; Lacerda, Acioly Luiz Tavares de Lacerda [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background: Although cognitive deficits have consistently been characterized as core features of schizophrenia, they have not been incorporated into definitions of remission. Furthermore, just a few studies have examined the relationship between cognitive deficits and symptomatic remission. The main aim of the present study is to evaluate the executive functioning of schizophrenia patients, particularly examining the neuropsychological correlates of remission. Methods: 72 remitted and 42 nonremitted schizophrenia patients, and 119 matched controls were examined. Subjects were tested with a comprehensive battery of cognitive tests, including a measure to assess the general components of executive functioning and individual tasks to tap the three specific executive dimensions assessed in the present study, namely updating, shifting and inhibition. Results: Schizophrenia subjects performed poorly on general executive functioning and shifting tasks in comparison to healthy controls. Nonremitted subjects performed poorly on inhibition and updating tasks as compared to remitted subjects. Whereas being a male and showing decreases in updating increase the chances of being in the nonremitted schizophrenia subjects group, increases in shifting and updating enhance the odds of being in the healthy control group. Conclusion: The present findings suggest that executive function deficits are present in schizophrenia patients. In addition, specific executive processes appear to be associated to symptom remission. Future studies examining prospectively first-episode, drug naive subjects diagnosed with schizophrenia may be especially elucidative.