Navegando por Palavras-chave "parassonias do sono não-rem"

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    Parassonias do sono não-rem na doença de machado-joseph: avaliações clínica e polissonográfica
    (Universidade Federal de São Paulo (UNIFESP), 2014-08-31) Silva, Giselle Melo Fontes [UNIFESP]; Prado, Gilmar Fernandes Do Prado [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Indroduction: The majority of spinocerebellar ataxias (SCA) are autosomal dominant neurodegenerative disorders that affect the cerebellum and its connections, and have a marked clinical and genetic variability. The spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) is the most common worldwide. MJD is classically characterized by progressive ataxia and variable other motor and non-motor symptoms. Sleep disorders are common and include: REM sleep behavior disorder (RBD), restless legs syndrome (RLS), insomnia, excessive daytime sleepiness, excessive fragmentary myoclonus and sleep apnea. Objective: This study aims to characterize and to determinate the frequency of the NREM-related parasomnias and other sleep parameters and disorders in MJD patients compared to a control group. Materials and Methods: Forty-seven patients with clinical and genetic diagnosis of MJD and 47 control subjects were evaluated clinically and by polysomnography. Results: MJD patients had a higher frequency of arousals from slow wave sleep (p<0.001), parasomnias complaints (confusional arousal/sleep terrors p=0.001, RBD p<0.001 and nightmares p<0.001), REM sleep without atonia (p<0.001), periodic limb movements of sleep-PLMS index (p<0.001), duration and percentage of N3 sleep (p<0.001) and percentage of N1 sleep (p<0.001). However MJD patients had a lower duration of N2 sleep (p<0.001). Conclusion: These data expose that NREM-related parasomnias must be included in the spectrum of sleep disorders in MJD patients.