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- ItemAcesso aberto (Open Access)Avaliação da cicatrização após implantação da tela de polipropileno/poliglecaprone na correção do defeito produzido na parede abdominal em ratos: efeito da administração do óleo de copaíba e andiroba(Universidade Federal de São Paulo (UNIFESP), 2013-01-30) Yasojima, Edson Yuzur [UNIFESP]; Lopes Filho, Gaspar de Jesus [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: to evaluate the effects of copaiba and andiroba oil on the correction of abdominal defect treated with the use of polypropylene/polyglecaprone mesh in rats. Methods: a defect in the abdominal wall was created and corrected with polypropylene/polyglecaprone mesh in 60 rats. They were randomly divided into five groups: control, copaiba by oral administration (gavage), andiroba by gavage, copaiba oil dip in the mesh and andiroba oil dip in the mesh. Euthanasia was performed after 7, 14 and 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects. Results: all animals had abdominal adhesions, which were smaller in the copaiba (gavage) group (p<0.05). In microscopy, all animals had an acute inflammation stage and the inflammatory response was best characterized by foreign body-type granulomas around the mesh fragments, which was not found in the mesh fragments within the copaiba dip group. There was a greater area of necrosis and fibrosis in the copaiba and andiroba dip group compared to the control group (p<0.05). The copaiba and andiroba (gavage) groups had a greater quantity of collagen fibers compared to the control group. Conclusion: The copaiba and andiroba gavage groups showed a modulation of the inflammatory response, as evidenced by the reduced amount of adhesion without impair the healing process. Since the oils shortened the process of forming collagen fibers. However, when used by dip directly on the mesh, it had corrosive effects compromising the healing process of the abdominal wall.
- ItemSomente MetadadadosAvaliação da cicatrização após implantação da tela de polipropileno/poliglecaprone na correção do defeito produzido na parede abdominal em ratos: efeito da administração do óleo de copaíba e andiroba(Universidade Federal de São Paulo (UNIFESP), 2013-01-30) Yasojima, Edson Yuzur [UNIFESP]; Lopes Filho, Gaspar de Jesus Lopes Filho [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: to evaluate the effects of copaiba and andiroba oil on the correction of abdominal defect treated with the use of polypropylene/polyglecaprone mesh in rats. Methods: a defect in the abdominal wall was created and corrected with polypropylene/polyglecaprone mesh in 60 rats. They were randomly divided into five groups: control, copaiba by oral administration (gavage), andiroba by gavage, copaiba oil dip in the mesh and andiroba oil dip in the mesh. Euthanasia was performed after 7, 14 and 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects. Results: all animals had abdominal adhesions, which were smaller in the copaiba (gavage) group (p<0.05). In microscopy, all animals had an acute inflammation stage and the inflammatory response was best characterized by foreign body-type granulomas around the mesh fragments, which was not found in the mesh fragments within the copaiba dip group. There was a greater area of necrosis and fibrosis in the copaiba and andiroba dip group compared to the control group (p<0.05). The copaiba and andiroba (gavage) groups had a greater quantity of collagen fibers compared to the control group. Conclusion: The copaiba and andiroba gavage groups showed a modulation of the inflammatory response, as evidenced by the reduced amount of adhesion without impair the healing process. Since the oils shortened the process of forming collagen fibers. However, when used by dip directly on the mesh, it had corrosive effects compromising the healing process of the abdominal wall.
- ItemSomente MetadadadosEstudo compDa respInflamLocal, morfometria do colágeno e aderências viscerais das telas de eptfe, polipropileno encapsulada com polidioxanona e revestida com celulose oxidada, propileno e propileno revestida com silicone, qdo em contato com as vísce(Universidade Federal de São Paulo (UNIFESP), 2014-12-17) Fuziy, Rogerio Aoki [UNIFESP]; Linhares, Marcelo Moura Linhares [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Purpose: Incisional Hernia repair is a frequent surgery, and the use of prosthetic mesh on an intra peritoneal position remains a challenge. The high recurrence rate in incisional hernias (45 to 54%) after primary suture has stimulated the development of prosthetic meshes. Currently, meshes are the biomaterials implant group most used in medicine, but its implants raises inflammatory complications like seroma, cellulite, chronic pain, and infection. This study aims to compare the visceral adhesions and tissue inflammatory responses and collagen deposition caused by meshes made of ePTFE, polypropylene coated with oxidated cellulose, polypropylene, polypropylene coated with silicon, on an experimental study in rats. Methods: Sixty Wistar rats were divided into four groups according with the mesh implanted: ePTFE mesh (group A) polypropylene mesh covered oxidated cellulose (group B), polypropylene (group C) and polypropylene mesh with silicon on the visceral site (group D). On seventh pos operative day, the region of the implanted mesh was accessed and the adhesions were analyzed by Zuhlke Adhesions score. Hematoxylin-eosin and Masson’s trichrome colorations were used to value the tissue inflammatory reaction with a numeric scale for objective scoring. Imunohistochemistry for COX2 was made. For collagen, picrosirius was used with data reading using the Image Tool computer software. Results The scale adhesion was observed that the group C had the highest percentage of adhesions in the classifications 3 and 4 (more dense) as compared to the groups A, B and D (93% vs. 13%, 0 % and 0 %, respectively, p <0.001). Groups A and C showed the greatest percentage area covered with adhesions when compared to groups B and D (99.8 % and 97.7 % vs 83.2 % and 63.1% , respectively, p < 0.001) , group A showed lower unincorporated area of the mesh compared to groups B , C and D ( 42.1 % vs. 15.4 % , 9.4 % and 14.6 % , respectively , p < 0.001 ) . When evaluating the adhesions to the abdominal viscera, the polypropylene mesh (group C) had the highest rates when compared to groups A, B and D (78.6 % vs. 26.7 %, 53.3 % and 35.7 %, respectively, p < 0.029). The ePTFE mesh (group A) showed seroma or collections in 100% of animals compared to groups B, C and D (66.7 %, 21.4 % and 35.7 %, respectively, p < 0.001). The histological study of the inflammatory response on the seventh postoperative day group A had higher scores in inflammation score compared to Group B, C and D (respectively 20.9 x 20.2, 18.6 and 18.2, p < 0.001). Immunohistochemical study in the seventh pos operative day, there was a higher expression of COX2 (p < 0.001) also in group A, compared to the other groups. There was no difference between groups regarding the morphology of collagen. Conclusions : The density of adhesions was higher in group C and lowest in group D; area covered with adhesions was higher on the groups A and C; the unincorporated area of the mesh was bigger on group A , and there were no differences between the others; there was significant difference between groups when compared to the presence of visceral adhesions , being of greater degree in group C and smaller in group A; the presence of collection, seroma or hematoma was higher in group A and lowest in group C; was significant difference between groups when compared to inflammatory classification, being greater degree in group A and lowest in group D; no significant difference was found between the groups when compared collagen deposition assessed by staining Picrosirus ; the intensity of inflammation assessed by the presence of COX2 was higher in group A and lower in the group D.
- ItemSomente MetadadadosEstudo da integração da tela de polipropileno recoberta com materiais nanoestruturados em ratos(Universidade Federal de São Paulo (UNIFESP), 2014-05-28) Tussi Júnior, Roberto [UNIFESP]; Koh, Ivan Hong Jun Koh [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Purpose: Evaluate the biocompatibility of polypropylene mesh coated with nanostructured materials and analysis of abdominal content adhesions with polypropylene mesh. Methods: After deposition of silver, carbon and carbon plus silver nanoparticles, using the Nonthermal plasma technique at Plasma and Processes Laboratory of ITA. The meshes were implanted at acute defects of the anterior abdominal wall of female rats Wistar- EPM. The histology was used to analysis of mesh tissue interaction using HE and Picrosirius Red. The study of adhesions was done through sheer numbers of adhesions to the prosthesis, Zühlke criteria for adhesion strength and Diamond criteria for percentage of area covered by adhesions. Results: The polypropylene mesh coated with carbon and silver exclusively demonstrated an excellent biocompatibility with the absence of acute or chronic inflammatory response and with reduced type I collagen and increase type III collagen. However meshes treated with carbon and silver in the sequence presented with harmful perpetuation of acute inflammatory activity. In this group the fibroblasts collagen production was absent. Evidencing a higher degree of antigenicity than control group. The analysis of the number of adhesions was not statistically significant between groups, as well as the strength of the same Zühlke criteria. Already the percentage of area attached to the prosthetic tissue showed statistical significance in the groups covered with silver carbon and unique compared to the polypropylene group. Conclusion: The deposition of nanocomposites of silver and carbon on the polypropylene mesh showed a reduction of antigenicity with improved tissue incorporation. The percentage of mesh surgical adhesions were also benefited this group. Nanotechnological meshes treatment did not prevent the formation of adhesions. Different Nonthermal methods deposition and combinations of nanoparticles may influence with the biological response.