Navegando por Palavras-chave "vasculite"

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    Angeíte isolada do sistema nervoso central em paciente com síndrome mielodisplásica: relato de caso
    (Academia Brasileira de Neurologia - ABNEURO, 2004-06-01) Silva, Gisele Sampaio [UNIFESP]; Siqueira Neto, José Ibiapina; Frota, Norberto Anísio Ferreira; Martins, Gabriela Joca; Castro, José Daniel Vieira De; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Ceara; Universidade de São Paulo (USP); Universidade Federal do Ceara Hospital das Clínicas; Universidade Federal do Ceará
    Isolated central nervous system (CNS) angiitis are vasculitides of undetermined etiology in which only nervous system vessels are affected. In most cases there is no associated systemic disease. We report the case of a 67 years old man with previous hematologic diagnosis of myelodysplastic syndrome who developed an isolated CNS angiitis.
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    Osteonecrose em pacientes com lúpus eritematoso sistêmico
    (Sociedade Brasileira de Reumatologia, 2005-02-01) Sella, Elaine Marcelina Claudio [UNIFESP]; Carvalho, Maria Rosenilda Petronila de [UNIFESP]; Sato, Emilia Inoue [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Osteonecrosis is a relatively common complication in systemic lupus erythematosus (SLE) patients. OBJECTIVE: To evaluate the possible risk factors associated with osteonecrosis in SLE patients. METHODS: SLE patients [according to American College of Rheumatology (ACR) criteria] who presented osteonecrosis were included in this study. SLE patients with no symptomatic osteonecrosis constituted the control group. Osteonecrosis was confirmed by radiographic evaluation, bone scintigraphy and/or magnetic resonance imaging. RESULTS: The study group was constituted by 14 SLE patients with osteonecrosis (10 women and 4 men, 64% of them white, 33 ± 13 years old and 120 ± 67 months of disease duration). Sex and time of SLE diagnosis matched patients without osteonecrosis constituted the control group (n = 14, 57% of them white, 33 ± 7 years old and 111 ± 54 months of SLE). Systemic lupus international collaborating clinics/ACR damage index for SLE (SLICC/ACR-DI) score was higher in patients with osteonecrosis (4 ± 1) compared with control group (1 ± 1) [p < 0.001]. Patients with osteonecrosis had higher number of other musculoskeletal irreversible damage when compared with the control group (29% versus 0, respectively; p = 0.034). Digital vasculitis was the variable associated with osteonecrosis (p = 0.021). There was no significant association between duration of prednisone use or prednisone cumulative dose and osteonecrosis in patients with regular follow-up at the Institution (p = 0.624 and p = 0.806, respectively). CONCLUSIONS: Previous history of digital vasculitis was a risk factor for the development of osteonecrosis. Patients with digital vasculitis history had 9 times more risk to present osteonecrosis than patients without previous vasculitis.
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    Púrpura de Henoch-Schönlein: recorrência e cronicidade
    (Sociedade Brasileira de Pediatria, 2007-04-01) Alfredo, Camila S. [UNIFESP]; Nunes, Nicole Acacia Cabral [UNIFESP]; Len, Claudio Arnaldo [UNIFESP]; Barbosa, Cassia Maria Passarelli Lupoli [UNIFESP]; Terreri, Maria Teresa Ramos Ascensão [UNIFESP]; Hilário, Maria Odete Esteves [UNIFESP]; ; Universidade Federal de São Paulo (UNIFESP)
    OBJECTIVES: To describe a group of patients treated at our service for Henoch-Schönlein purpura, with emphasis on recurrent and chronic cases, and to compare clinical and demographic characteristics of patients with monocyclic and recurrent disease. METHODS: Data on 67 patients who had been treated since disease onset were analyzed. Twelve patients were excluded because they failed to return for follow-up consultations after less than 3 months, leaving a total of 55 children in the study sample. Recurrence was defined as the presence of a fresh episode after a period of at least 3 months without symptoms, and cases were defined as chronic when cutaneous, abdominal and renal manifestations persisted for a period of 12 months or more. RESULTS: Recurrence was observed in 8/55 patients (14.4%) and four cases were chronic (7.2%). In 29/55 patients (52.7%), infection was identified as the trigger factor. A monocyclic clinical course was observed in 43 patients (26 of whom were girls, with a mean age of 5.4 years). Gastrointestinal and renal involvement was observed in 55.8 and 20.9% of patients, respectively. Among the 12 patients with recurrent or chronic Henoch-Schönlein purpura, three had arthritis, four exhibited signs and symptoms of abdominal involvement and seven of kidney disease: microscopic hematuria in five, macroscopic hematuria in one and hematuria with proteinuria in one other. Late onset was the only variable related to recurrence (p < 0.05). CONCLUSIONS: As is observed in medical literature, monocyclic cases are more common among children with early onset disease. Patients with Henoch-Schönlein purpura should be followed over the long term, since recurrent and chronic cases account for more than 20% of the total.
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    Vasculite cutânea induzida por propiltiouracil
    (Sociedade Brasileira de Reumatologia, 2008-02-01) Milanez, Fernanda Manente; Costa, Leonardo Atem Gonçalves A.; José, Fábio Freire [UNIFESP]; Enokihara, Milvia M. S. S. [UNIFESP]; Souza, Alexandre Wagner Silva de [UNIFESP]; Hospital do Servidor Público Estadual Francisco Morato de Oliveira; Universidade Federal de São Paulo (UNIFESP)
    The use of propylthiouracil (PTU) is associated with the development of different auto-antibodies, amongst them are antineutrophil cytoplasmic antibodies (ANCA) that are involved in the pathogenesis of ANCA associated systemic vasculitis. The case of a 46-years old woman who presented cutaneous vasculitis when taking PTU for Graves' disease is reported. Perinuclear ANCA (p-ANCA) was positive with titer > 1/320, but anti-myeloperoxidase antibodies were not detected. Skin biopsy showed leucocytoclastic vasculitis. The patient improved within ten days after withdrawing PTU and the resolution of hyperthyroidism was achieved with radioiodine (131I). The p-ANCA test remained positive > 1/320 eight months and four years after PTU withdrawal.