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    Estudo da participação da proteína impact nos efeitos da restrição calórica em cElegans
    (Universidade Federal de São Paulo (UNIFESP), 2015-06-24) Conceicao, Rafael Ferraz [UNIFESP]; Mori, Marcelo Alves da Silva Mori [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    In recent decades, obesity has come to become a major global public health problem, resulting in the increased prevalence of chronic diseases such as coronary heart disease, type 2 diabetes, cancer, among others. Likewise, the increase in the elderly population has contributed to the increased incidence of these and other chronic diseases. Data in the literature suggest that caloric restriction may be an etfective intervention to combat the evils arising from obesity and aging, despi te the practical limitations underlying prolonged food restriction. Therefore, it is important that nutritional or pharmacological alternatives are developed to mimic the effects of caloric restriction without its deleterious etfects. Recent1y, it was demonstrated that the restriction of specific amíno acíds is sufficient to promote some acute effects of caloric restriction in mice, this being dependent on GCN2, a kinase activated by amino acid restriction that controls protein synthesis and stress responses. Our group and other groups also showed that the miRNA processing pathway is essential for the effects of caloric restriction to take place, whereas overexpression of Dicer, an enzyme important in the synthesis of miRNAs, leads to an increase in life expectancy and stress resistance in the nematode C. elegans. Thus, to better define the mechanisms of action of caloric restriction in relation to life expectancy and stress resistance, we will use C. elegans to test: 1) whether the GCN2 pathway controls lifespan, stress response and lipid accumulation of nematodes and 2) whether this pathway operates in the promotion of longevity and stress resistance induced by caloric restriction or Dicer overexpression. With this, we aim to contribute to the understanding ofthe mechanisms of action of caloric restriction, hoping to