Transcriptional regulatory elements in the rat bradykinin B-2 receptor gene
Data
1996-06-01
Autores
Pesquero, João Bosco 
Lindsey, Charles Julian
Paiva, Antonio Cechelli de Mattos
Tipo
Artigo
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ISSN da Revista
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Resumo
In an attempt to elucidate the mechanisms underlying the regulation of bradykinin B2 receptor gene expression, the molecular structure of the rat gene including the 5'-flanking region was characterized (J. Biol. Chem. 269: 26920-26925, 1994). in this study we show that the gene spans about 32 kb, including a long first intron of 25 kb. the promoter region drives reporter gene expression in NG108-15 neuroglioma cells, and its expression is upregulated by cAMP bradykinin, phorbol esters and by coexpression of an activated ras oncogene but not by dexamethasone.
Descrição
Citação
Immunopharmacology. Amsterdam: Elsevier B.V., v. 33, n. 1-3, p. 36-41, 1996.