Transcriptional regulatory elements in the rat bradykinin B-2 receptor gene
| dc.contributor.author | Pesquero, João Bosco [UNIFESP] | |
| dc.contributor.author | Lindsey, Charles Julian [UNIFESP] | |
| dc.contributor.author | Paiva, Antonio Cechelli de Mattos [UNIFESP] | |
| dc.contributor.author | Ganten, Detlev | |
| dc.contributor.author | Bader, Michael | |
| dc.contributor.institution | MAX DELBRUCK CTR MOLEC MED | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2016-01-24T11:40:32Z | |
| dc.date.available | 2016-01-24T11:40:32Z | |
| dc.date.issued | 1996-06-01 | |
| dc.description.abstract | In an attempt to elucidate the mechanisms underlying the regulation of bradykinin B2 receptor gene expression, the molecular structure of the rat gene including the 5'-flanking region was characterized (J. Biol. Chem. 269: 26920-26925, 1994). in this study we show that the gene spans about 32 kb, including a long first intron of 25 kb. the promoter region drives reporter gene expression in NG108-15 neuroglioma cells, and its expression is upregulated by cAMP bradykinin, phorbol esters and by coexpression of an activated ras oncogene but not by dexamethasone. | en |
| dc.description.affiliation | MAX DELBRUCK CTR MOLEC MED,D-13125 BERLIN,GERMANY | |
| dc.description.affiliation | ESCOLA PAULISTA MED,DEPT BIOPHYS,BR-04023062 São Paulo,BRAZIL | |
| dc.description.affiliationUnifesp | ESCOLA PAULISTA MED,DEPT BIOPHYS,BR-04023062 São Paulo,BRAZIL | |
| dc.description.source | Web of Science | |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | pt |
| dc.format.extent | 36-41 | |
| dc.identifier | https://dx.doi.org/10.1016/0162-3109(96)00080-X | |
| dc.identifier.citation | Immunopharmacology. Amsterdam: Elsevier B.V., v. 33, n. 1-3, p. 36-41, 1996. | |
| dc.identifier.doi | 10.1016/0162-3109(96)00080-X | |
| dc.identifier.issn | 0162-3109 | |
| dc.identifier.uri | https://repositorio.unifesp.br/handle/11600/25601 | |
| dc.identifier.wos | WOS:A1996VA29800006 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier B.V. | |
| dc.relation.ispartof | Immunopharmacology | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
| dc.subject | Bradykinin | en |
| dc.subject | Receptor | en |
| dc.subject | Gene | en |
| dc.subject | Promoter | en |
| dc.subject | cAMP | en |
| dc.subject | ras oncogene | en |
| dc.title | Transcriptional regulatory elements in the rat bradykinin B-2 receptor gene | en |
| dc.type | info:eu-repo/semantics/article |