Nomogram of fetal middle cerebral artery peak systolic velocity at 23-35 weeks of gestation in a Brazilian population: Pilot study
Data
2008-01-01
Autores
Machado Nardozza, Luciano Marcondes 
Simioni, Christiane
Garbato, Gabriel
Araujo Junior, Edward
Guimaraes Filho, Helio Antonio
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Objective. To establish normative data for the peak systolic velocity of the middle cerebral artery (MCA-PSV) of fetuses in the second half of pregnancy using multiples of the median and percentile reference range. Methods. A cross-sectional study was performed in 90 healthy fetuses at between 23 and 35 weeks of gestation. A bi-dimensional axial scan of the brain, including the thalami and cavitas septi pellucidi was obtained. the circle of Willis was visualized using color flow mapping. Pulsed-wave Doppler velocimetry of the MCA was performed close to the artery's origin, with a beam-vessel angle below 20. A table with the multiples of the median (MoM) of the MCA-PSV for each gestational age was generated and Pearson's correlation coefficient (r) was calculated. Regression modeling across gestational age was performed to obtain the reference values. Results. There was a strong correlation between the MCA-PVS and gestational age (r=0.70; p0.001). Values for the MCA-PSV for the following MoM were calculated: 1.0, 1.29, 1.50, and 1.55. the MCA-PSV 2.5th and 97.5th centiles ranged from 24.33cm2/s to 78.36cm2/s, respectively, between weeks 23 and 35. Conclusions. A nomogram for the fetal MCA-PSV during the second half of pregnancy was generated.
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Journal of Maternal-fetal & Neonatal Medicine. Abingdon: Taylor & Francis Ltd, v. 21, n. 10, p. 714-718, 2008.