Can the Induction of Labor with Misoprostol Increase Maternal Blood Loss?
Data
2017
Autores
Araujo Junior, Edward 
Tipo
Artigo
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Purpose To evaluate blood loss during misoprostol-induced vaginal births and during cesarean sections after attempted misoprostol induction. Methods We conducted a prospective observational study in 101 pregnant women indicated for labor induction
pre-and postpartum hemoglobin levels were measured to estimate blood loss during delivery. Labor was induced by administering 25 mu g vaginal misoprostol every 6 hours (with a maximum of 6 doses). The control group included 30 patients who spontaneously entered labor, and 30 patients who underwent elective cesarean section. Pre-and postpartum hemoglobin levels were evaluated using the analysis of variance for repeated measurements, showing the effects of time (pre-and postpartum) and of the group (with and withoutmisoprostol administration). Results Therewere significant differences between pre-and postpartum hemoglobin levels (p < 0.0001) with regard to misoprostol-induced vaginal deliveries (1.6 +/- 1.4 mg/dL), non-induced vaginal deliveries (1.4 +/- 1.0 mg/dL), cesarean sections after attempted misoprostol induction (1.5 +/- 1.0 mg/dL), and elective cesarean deliveries (1.8 +/- 1.1 mg/dL). However, the differences were proportional between the groups with and without misoprostol administration, for both cesarean (p = 0.6845) and vaginal deliveries (p = 0.2694). Conclusions Labor induction using misoprostol did not affect blood loss during delivery.
pre-and postpartum hemoglobin levels were measured to estimate blood loss during delivery. Labor was induced by administering 25 mu g vaginal misoprostol every 6 hours (with a maximum of 6 doses). The control group included 30 patients who spontaneously entered labor, and 30 patients who underwent elective cesarean section. Pre-and postpartum hemoglobin levels were evaluated using the analysis of variance for repeated measurements, showing the effects of time (pre-and postpartum) and of the group (with and withoutmisoprostol administration). Results Therewere significant differences between pre-and postpartum hemoglobin levels (p < 0.0001) with regard to misoprostol-induced vaginal deliveries (1.6 +/- 1.4 mg/dL), non-induced vaginal deliveries (1.4 +/- 1.0 mg/dL), cesarean sections after attempted misoprostol induction (1.5 +/- 1.0 mg/dL), and elective cesarean deliveries (1.8 +/- 1.1 mg/dL). However, the differences were proportional between the groups with and without misoprostol administration, for both cesarean (p = 0.6845) and vaginal deliveries (p = 0.2694). Conclusions Labor induction using misoprostol did not affect blood loss during delivery.
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Citação
Revista Brasileira De Ginecologia E Obstetricia. Rio De Janeiro Rj, v. 39, n. 2, p. 53-59, 2017.