Children recovered from malnutrition exhibit normal insulin production and sensitivity
Data
2008-02-01
Autores
Martins, Vinícius José Baccin 
Martins, Paula Andrea
Neves, Janaina das
Sawaya, Ana Lydia
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Protein-energy malnutrition promotes adaptive hormonal changes that result in stunting. A previous study showed that stunted children had increased insulin sensitivity and diminished pancreatic P-cell function. the objectives of the present study were to analyse the glucose, insulin, homeostasis model assessment of insulin sensitivity (HOMA-S) and homeostasis model assessment of pancreatic P-cell function (HOMA-B) levels after nutritional recovery. the recovered group (n 62) consisted of malnourished children after treatment at a nutrition rehabilitation centre. At the beginning of treatment their age was 2.41 (SD 1.28) and 2.31 (SD 1.08) years, weight-for-age Z score -2.09 (SD 0.94) and -2.05 (SD 0.55) and height-for-age Z score - 1.85 (SD 1.11) and - 1.56 (SD 0.90), for boys and girls respectively. the control group consisted of well-nourished children without treatment (n 26). After treatment, boys of the recovered group gained 1.29 (SD 1.06) Z scores of height-for-age and 1.14 (SD 0-99) Z scores of weight-for-age, and girls, 1.12 (SD 0.91) and 1.21 (SD 0-74) Z scores respectively. No differences were found between control and recovered groups in insulin levels for boys (P=0.704) and girls (P=0.408), HOMA-B for boys (P=0.451) and girls (P=0.330), and HOMA-S (P=0.765) for boys and girls (P=0-456) respectively. the present study shows that the changes observed previously in glucose metabolism and insulin were reverted in children who received adequate treatment at nutritional rehabilitation centres and showed linear catch-up.
Descrição
Citação
British Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 99, n. 2, p. 297-302, 2008.