Children recovered from malnutrition exhibit normal insulin production and sensitivity
| dc.contributor.author | Martins, Vinícius José Baccin [UNIFESP] | |
| dc.contributor.author | Martins, Paula Andrea [UNIFESP] | |
| dc.contributor.author | Neves, Janaina das [UNIFESP] | |
| dc.contributor.author | Sawaya, Ana Lydia [UNIFESP] | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2016-01-24T13:49:33Z | |
| dc.date.available | 2016-01-24T13:49:33Z | |
| dc.date.issued | 2008-02-01 | |
| dc.description.abstract | Protein-energy malnutrition promotes adaptive hormonal changes that result in stunting. A previous study showed that stunted children had increased insulin sensitivity and diminished pancreatic P-cell function. the objectives of the present study were to analyse the glucose, insulin, homeostasis model assessment of insulin sensitivity (HOMA-S) and homeostasis model assessment of pancreatic P-cell function (HOMA-B) levels after nutritional recovery. the recovered group (n 62) consisted of malnourished children after treatment at a nutrition rehabilitation centre. At the beginning of treatment their age was 2.41 (SD 1.28) and 2.31 (SD 1.08) years, weight-for-age Z score -2.09 (SD 0.94) and -2.05 (SD 0.55) and height-for-age Z score - 1.85 (SD 1.11) and - 1.56 (SD 0.90), for boys and girls respectively. the control group consisted of well-nourished children without treatment (n 26). After treatment, boys of the recovered group gained 1.29 (SD 1.06) Z scores of height-for-age and 1.14 (SD 0-99) Z scores of weight-for-age, and girls, 1.12 (SD 0.91) and 1.21 (SD 0-74) Z scores respectively. No differences were found between control and recovered groups in insulin levels for boys (P=0.704) and girls (P=0.408), HOMA-B for boys (P=0.451) and girls (P=0.330), and HOMA-S (P=0.765) for boys and girls (P=0-456) respectively. the present study shows that the changes observed previously in glucose metabolism and insulin were reverted in children who received adequate treatment at nutritional rehabilitation centres and showed linear catch-up. | en |
| dc.description.affiliation | Universidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil | |
| dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil | |
| dc.description.source | Web of Science | |
| dc.format.extent | 297-302 | |
| dc.identifier | https://dx.doi.org/10.1017/S0007114507793959 | |
| dc.identifier.citation | British Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 99, n. 2, p. 297-302, 2008. | |
| dc.identifier.doi | 10.1017/S0007114507793959 | |
| dc.identifier.issn | 0007-1145 | |
| dc.identifier.uri | https://repositorio.unifesp.br/handle/11600/30433 | |
| dc.identifier.wos | WOS:000253045600013 | |
| dc.language.iso | eng | |
| dc.publisher | Cambridge Univ Press | |
| dc.relation.ispartof | British Journal of Nutrition | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.license | http://journals.cambridge.org/action/displaySpecialPage?pageId=4676 | |
| dc.subject | Stunting | en |
| dc.subject | Nutritional recovery | en |
| dc.subject | Insulin sensitivity | en |
| dc.subject | Homeostasis model assessment | en |
| dc.title | Children recovered from malnutrition exhibit normal insulin production and sensitivity | en |
| dc.type | info:eu-repo/semantics/article |