Navegando por Palavras-chave "hemoglobin"
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- ItemSomente MetadadadosAnemia reduction in preschool children with the addition of low doses of iron to school meals(Oxford Univ Press, 2008-08-01) Arcanjo, Francisco Placido Nogueira [UNIFESP]; Pinto, Vicente de Paulo Teixeira; Coelho, M. R.; Amancio, Olga Maria Silverio [UNIFESP]; Magalhaes, S. M. M.; Univ Fed Ceara; Secretariat Educ Sobral; Universidade Federal de São Paulo (UNIFESP)Background. in developing countries there is high prevalence of iron deficiency anemia, which causes negative impact on growth, development and quality of life for infant population. Currently several strategies are being elaborated and tested to tackle this problem. Objective. To measure anemia prevalence in preschool children. To evaluate fortification effectiveness with 5 or 10 mg of elemental iron/daily added to school meals by increasing hemoglobin levels in anemic children. Methods. Double-blind, cluster randomized intervention study with 728 students from public network. Blood count was taken at beginning of study, to evaluate anemia prevalence, those anemic were selected for intervention, after intervention new blood count was taken to evaluate fortification effectiveness. Ferrous Sulphate was added in individual dosage of 5 or 10 mg of elemental iron/daily to usual school meal. From 35 schools 3 were randomized to receive 5 mg/daily (group A) and 3 to receive 10 mg/daily (group B). Hemoglobin and hematocrit averages before and after intervention were compared in each group and between them. Results. in group A, the anemia prevalence reduced 34.9 to 12.4%, and in group B 39.0 to 18.7%. in both groups a significant increase in hemoglobin was observed: in group A from 10.1 to 11.5 g/dl (p < 0.01) and in group B from 10.0 to 11.0 g/dl (p < 0.01). There was no statistically significant difference in final levels of hemoglobin among groups. Conclusions. Both dosages of elemental iron were equally effective in increasing hemoglobin levels, and reducing anemia prevalence. Fortification of school meals was shown to be an effective, low cost and easy to manage intervention.
- ItemAcesso aberto (Open Access)Breastfeeding exclusively and iron deficiency anemia during the first 6 months of age(Associação Médica Brasileira, 2014-02-01) Marques, Rosa Fátima da Silva Vieira [UNIFESP]; Taddei, Jose Augusto de Aguiar Carrazedo [UNIFESP]; Lopez, Fábio Ancona [UNIFESP]; Braga, Josefina Aparecida Pellegrini [UNIFESP]; State University of Pará Department of Integral Health Professor; Universidade Federal de São Paulo (UNIFESP)Objective The objective was to determine the prevalence of iron deficiency and iron deficiency anemia among exclusively breastfed infants from one to six months of life and to identify associated risk factors. Methods This is a cohort study of the hemoglobin and serum ferritin levels of 102 healthy full-term infants, weighing more than 2500 grams (5.5 pounds) at birth, evaluated for growth development and supported to promote exclusive breastfeeding. Hemoglobin and ferritin levels were measured in the first, fourth, and sixth months of life. The hemoglobin and ferritin levels of the mothers were also measured in the first month postpartum. Results At four months, 5.7% presented iron deficiency and 3.4% had iron deficiency anemia. At six months, the percentage of children with iron deficiency increased more than four times, reaching 26.1%, while iron deficiency anemia was present in 23.9% of the infants studied. Iron deficiency at six months of age was significantly correlated to growth velocity. Conclusion According to the results of this study, exclusive breastfeeding protects infants from iron deficiency and iron deficiency anemia for the first four months of life. After this age, in accordance with the literature, the findings of this study demonstrated an increase in anemia and iron deficiency rates, adding to evidence that supports the monitoring of iron levels in exclusively breastfed children presenting higher weight gains beginning at four months of age.
- ItemAcesso aberto (Open Access)Can the Induction of Labor with Misoprostol Increase Maternal Blood Loss?(Federacao Brasileira Soc Ginecologia & Obstetricia-Febrasgo, 2017) Praciano Souza, Paulo Cesar; Azevedo Damasceno, Karla Santana; Araujo Junior, Edward [UNIFESP]; Alencar Junior, Carlos Augusto; de Lucena Feitosa, Francisco EdsonPurpose To evaluate blood loss during misoprostol-induced vaginal births and during cesarean sections after attempted misoprostol induction. Methods We conducted a prospective observational study in 101 pregnant women indicated for labor induction
- ItemSomente MetadadadosThe liver monooxygenase system of Brazilian freshwater fish(Elsevier B.V., 2000-05-01) Leitao, MAS; Affonso, E. G.; Silva, MFE da; Meirelles, N. C.; Rantin, F. T.; Vercesi, A. E.; Junqueira, VCB; Degterev, I. A.; Universidade Federal de São Carlos (UFSCar); Universidade de São Paulo (USP); Universidade Estadual de Campinas (UNICAMP); Universidade Federal de São Paulo (UNIFESP); Russian Acad SciContent of cytochromes b(5) and P-450, and activities of NADPH-cytochrome c (P-450) reductase (NCR) and 7-ethoxyresorufin O-deethylase (EROD) were measured in liver microsomes prepared from two South American endemic fish, Brycon cephalus and Colossoma macropomum, from tilapia, Oreochromis niloticus, and from Swiss mice, Mus musculus. which served as a control. Strong hemoglobin binding to fish liver microsomal membranes (FLM) altered visible spectra of microsomal cytochromes. Consequently, special precautions during FLM preparation, including liver perfusion followed by repeated washing of microsomes, were required in the study of microsomal cytochromes from these fish. FLM from all fish studied here had a significantly lower content of microsomal cytochromes but a similar level of NCR and EROD activities compared to mouse liver microsomes (MLM). Strong response of the monooxygenase system in O. niloticus to water pollution was detected with both specific cytochrome P-450 content and EROD activity increasing sharply. the optical spectra of hemoglobin from B. cephalus and C. macropomum were analyzed and some differences in shape and relative extinction were observed compared to known hemoglobins. (C) 2000 Elsevier Science Inc. All lights reserved.
- ItemSomente MetadadadosRandomized Controlled Trial of Iron-Fortified Drinking Water in Preschool Children(Routledge Journals, Taylor & Francis Ltd, 2010-04-01) Arcanjo, Francisco Placido Nogueira [UNIFESP]; Amancio, Olga Maria Silverio [UNIFESP]; Braga, Josefina Aparecida Pellegrini [UNIFESP]; Pinto, Vicente de Paulo Teixeira; Free Univ Brussels; Prime Hlth Consultants Inc; Univ Pittsburgh; Baylor Univ; Univ Queensland; Hosp ABC Mexico; Miami Childrens Hosp; Universidade Federal de São Paulo (UNIFESP); Inst Nacl Salud; Univ Seville; Ponce Sch Med; Univ Nebraska; Univ Hong Kong; Mead Johnson Res CtrObjectives: To evaluate the effects of fortified drinking water. with different concentrations of iron added, on hemoglobin and hematocrit values in preschoolers.Methods: Double-blind, randomized cluster clinical trial, with children aged 2 to 5 years of age, from 4 state-run schools, forming 1 group for each school. For fortification, ferrous sulphate in concentrations of 5 mg of elemental iron per liter of water (group A), 7.5 mg (group B), and 10 mg (group C), was used during a period of 4 months. In group D, the control, a placebo (Bixa orellana) was added. Hemoglobin and hematocrit values were checked before and after intervention.Results: Before fortification, hemoglobin and hematocrit averages were below the reference values adopted in all groups. After fortification, the prevalence of anemia showed a reduction in the 4 groups, which was more pronounced in group B, at 48.3%. The hemoglobin values in groups B (11.5) and C (11.4) were statistically similar. However, the average consumption of water/day/student was lower in group C. Comparison of hemoglobin values between groups A (11.2) and D (11.0) did not show a significant difference, suggesting insignificant efficacy with 5 mg Fe/L fortification.Conclusions: The consumption of drinking water fortified with 7.5 mg of elemental iron/L water resulted in greater adhesion and an increase in hemoglobin values, with a reduction in the prevalence of anemia.
- ItemSomente MetadadadosVasoactive properties of synthetic blood substitutes(Medicina (buenos Aires), 1998-01-01) Figueiredo, Luis Francisco Poli de [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)There is a great need for the development of a safe and efficient blood substitute, to overcome the important limitations of homologous blood transfusion. Currently available cell-free hemoglobin-based oxygen-carrying solutions present oxygen transport and exchange properties similar to blood and potential benefits over conventional transfusion, including large supply, absence of transfusion reactions, no need for cross-matching, no risk for transmission of disease and long shelf life. Several experimental studies have suggested that cell-free hemoglobin is a vasoactive agent. In animal models of hemorrhagic shock, small doses of cell-free modified hemoglobin restore arterial pressure, promote adequate tissue oxygenation, and improve survival, when compared with fluids with no oxygen-carrying capacity. On the other hand, it has been demonstrated that hemoglobin-induced vasoconstriction may result in decreased cardiac output, reduced blood flow to vital organs and severe pulmonary hypertension. Cell-free hemoglobin solutions cause their presser effects by binding and scavenging nitric oxide. Although hemoglobin within the red blood cells is the natural scavenger of NO, when the hemoglobin is free in solution, NO is inactivated to a greater extend. Cell-free hemoglobins are on advanced clinical trials, despite the fact that several concerns raised by experimental studies have not been adequately addressed in early clinical trials. The development of a safe and efficient blood substitute depends on the availability of these products for critical evaluation by the scientific community before the widespread clinical use of these blood substitutes.